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Product Name:GHK-Cu

Cas No: 89030-95-5

Molar Mass:402.00

Chemical Formula:C14H22CuN6O4

Synonyms:Copper tripeptide

Storage:Store at -20°C

Sequence: Gly-His-Lys.Cu.xHAc

Target Indicators: Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells


Application: GHK-Cu(CAS: 89030-95-5) holds significant promise in various fields, notably pharmaceuticals and cosmetics. This peptide complex comprises glycyl-L-histidyl-L-lysine and copper, demonstrating multifaceted benefits. In pharmaceuticals, GHK-Cu exhibits remarkable regenerative properties, promoting wound healing, and tissue repair. Its action method involves stimulating collagen and elastin production, crucial for skin rejuvenation and wound closure. Furthermore, GHK-Cu showcases antioxidative and anti-inflammatory effects, contributing to its therapeutic potential in dermatology and wound care. In cosmetics, GHK-Cu’s properties extend to anti-aging formulations, where it enhances skin firmness, elasticity, and overall texture. Its ability to modulate gene expression and promote extracellular matrix synthesis underscores its role in skincare innovation. Additionally, GHK-Cu’s copper component serves as a cofactor for various enzymes involved in skin regeneration and repair processes. With its versatile applications spanning pharmaceuticals and cosmetics, GHK-Cu emerges as a promising compound driving advancements in skincare and regenerative medicine, offering solutions for diverse medical and aesthetic needs.

Current Research:GHK-Cu, a copper-binding tripeptide, has garnered attention as a potent biomimetic peptide for skincare and haircare applications. This highly hydrophilic peptide, consisting of glycine, histidine, and lysine, exhibits remarkable abilities in promoting skin healing and rejuvenation. GHK-Cu facilitates skin penetration and acts as a delivery system for copper ions, thereby enhancing their therapeutic effects. Notably, it accelerates the healing process by modulating matrix metalloproteinases expressions and promoting the synthesis of collagen, elastin, and glycosaminoglycans. Moreover, it demonstrates compatibility with dermal fibroblasts and aids in increasing collagen IV synthesis, especially when combined with hyaluronic acid. However, due to the hydrophilic nature of peptides like GHK-Cu, they face challenges in crossing the skin barrier effectively. To address this, various techniques such as modifying peptide polarity through acyl moiety addition and encapsulation in delivery systems like liposomes have been explored. Liposomes, in particular, offer advantages as they are biocompatible, biodegradable, and possess both hydrophilic and hydrophobic properties. Encapsulation of GHK-Cu in liposomes has shown promise in improving peptide permeability and enhancing its therapeutic efficacy. Our study focused on utilizing both cationic and anionic hydrogenated lecithin-based liposomes as carriers for GHK-Cu tripeptide. We investigated the influence of lipid composition and GHK-Cu concentration on liposome properties and stability. Our findings revealed that anionic liposomes exhibited higher encapsulation efficiency of GHK-Cu compared to cationic liposomes, likely due to additional electrostatic interactions. Moreover, we observed that anionic liposomes were compatible with GHK-Cu and non-cytotoxic towards skin cells. Additionally, our elastase and tyrosinase inhibition tests indicated the potential of GHK-Cu in reducing elastin degeneration, thereby supporting skin structural integrity. Overall, charged liposomes, particularly anionic ones, hold promise as effective carriers for GHK-Cu and offer potential applications in anti-aging cosmetics, considering their safety and compatibility with biomimetic peptides.

Reference:Dymek, M., Olechowska, K., Hąc-Wydro, K., & Sikora, E. (2023). Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application. Pharmaceutics, 15(10), 2485.

Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative medicine and cellular longevity, 2012.