Product Name: Semax
Cas No:80714-61-0
Molar Mass:813.9
Chemical Formula:C37H51N9O10S
Synonyms:ACTH (4-7)
Storage:Store at -20°C
Sequence: MEHFPGP
Target Indicators: an ACTH-like peptide, in particular an analog of the endogenous regulatory peptide ACTH (4–10) (Met-Glu-His-Phe-Arg-Trp-Gly)
Application: Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) sequence. It has neuroprotective and cognitive-enhancing properties, making it a subject of interest in pharmaceutical research for its potential therapeutic applications. In pharmaceutical chemistry, Semax is studied for its neuroprotective effects, which include promoting neuronal survival, enhancing cognitive function, and improving memory and learning abilities. It acts by modulating neurotransmitter levels, such as dopamine, serotonin, and norepinephrine, in the brain, which are involved in mood regulation and cognitive processes. Additionally, Semax has shown promise in treating neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, and improving outcomes in stroke and traumatic brain injury patients. Its mechanism of action in enhancing brain function and protecting against neuronal damage makes Semax a valuable candidate for developing treatments for neurological disorders and cognitive impairment.
Current Research:
Semax, a peptide derived from adrenocorticotropic hormone (ACTH), has garnered significant attention due to its diverse pharmacological effects and therapeutic potential. The wide-ranging physiological effects of Semax stem from its interactions with various receptors, including serotonin (5-HT), dopamine (DA), and gamma-aminobutyric acid (GABA) receptors, among others. Through allosteric interactions with these receptors, Semax induces conformational changes and functional modifications, thereby modulating signaling pathways and fine-tuning information signals.
Research into Semax has revealed its unique profile as both a natural peptide regulator and a product of synthetic peptide engineering. Derived from ACTH with minimal modifications, Semax retains the beneficial properties of natural peptide regulators while minimizing potential side effects. However, through synthetic peptide engineering, Semax offers additional properties and advantages, such as improved stability, enhanced efficacy, and reduced degradation.
The therapeutic potential of Semax spans various physiological systems, offering benefits in cognition, memory, attention, and neuronal protection. Semax’s ability to influence learning, memory consolidation, and environmental perception underscores its potential for cognitive enhancement. Furthermore, Semax exhibits neuroprotective effects, potentially mitigating neuronal damage and promoting neuronal survival in various pathological conditions.
The multifaceted nature of Semax’s pharmacological effects underscores its versatility as a therapeutic agent. Whether targeting cognitive function, neuroprotection, or neurotransmitter modulation, Semax demonstrates promising therapeutic profiles across diverse physiological systems. Moreover, ongoing research continues to uncover new insights into Semax’s mechanisms of action and potential applications, highlighting its importance as a subject of multidisciplinary investigation and a valuable addition to the medicinal arsenal.
