Carfilzomib intermediate-1

Product Name:Carfilzomib intermediate-1

Form:Free base

Purity:98%

Storage:-20^oC

Cas No:868540-16-3

Molar Mass:566.69

Chemical Formula:C31H42N4O6

Synonyms:CFLZ-567

IUPAC Name:(2S)-2-[[(2S)-4-methyl-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanoyl]amino]-3-phenylpropanoic acid

SMILES:OC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC2=CC=CC=C2)NC(CN3CCOCC3)=O)=O)CC(C)C)=O)=O

InChIKey:MIVQDKORYUSPTQ-QKDODKLFSA-N

InChI:InChI=1S/C31H42N4O6/c1-22(2)19-26(30(38)34-27(31(39)40)20-24-11-7-4-8-12-24)33-29(37)25(14-13-23-9-5-3-6-10-23)32-28(36)21-35-15-17-41-18-16-35/h3-12,22,25-27H,13-21H2,1-2H3,(H,32,36)(H,33,37)(H,34,38)(H,39,40)/t25-,26-,27-/m0/s1

Reference:Ic?ten, E., Maloney, A. J., Beaver, M. G., Shen, D. E., Zhu, X., Graham, L. R., ... & Braatz, R. D. (2020). A virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib drug substance intermediate, part 1: CDI-promoted amide bond formation. Organic Process Research & Development, 24(10), 1861-1875.