[Pyr11]-beta-Amyloid (11-42)

Product Name: [Pyr11]-beta-Amyloid (11-42)

Sequence One Letter Code: Pyr-VHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Sequence Three Letter Code: Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

Chemical Formula:C152H242N40O41S

Molecular Weight: 3318.2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: [Pyr11]-beta-Amyloid (11–42) is an N-terminally truncated amyloid peptide modified with pyroglutamate at position 11. This post-translational modification increases peptide hydrophobicity, aggregation propensity, and resistance to enzymatic degradation. Aβ(pE11–42) is a major amyloid species detected in Alzheimer’s disease brains and is associated with enhanced neurotoxicity compared with full-length amyloid peptides. This modified beta-amyloid peptide is commonly used to study amyloid maturation, aggregation dynamics, plaque formation, and disease-associated peptide processing. It is valuable for research on post-translationally modified amyloid species and their pathological roles in neurodegenerative disease.