Spexin

Product Name: Spexin

CAS No: 1370290-58-6

Purity: 95%

Molar Mass: 1619.9

Chemical Formula: C74H114N20O19S

Storage: Store at -20??

Sequence: NWTPQAMLYLKGAQ-NH2

Application:

Spexin is a peptide hormone that plays a critical role in regulating energy homeostasis, lipid metabolism, and body weight. It binds to the galanin receptors GALR2 and GALR3, influencing appetite suppression, insulin sensitivity, and fat storage. Spexin is involved in reducing food intake, increasing energy expenditure, and improving glucose metabolism, making it a significant target for research in obesity, diabetes, and metabolic disorders. Its ability to modulate these physiological processes suggests potential therapeutic applications for Spexin in managing metabolic syndrome, type 2 diabetes, and related conditions.

Current Research:

Spexin, also known as Neuropeptide Q (NPQ), is a conserved 14-amino-acid peptide that functions as a potent agonist for galanin receptors 2 and 3 (GALR2 and GALR3), with EC?? values of 45.7 nM and 112.2 nM, respectively. It exhibits negligible activity at galanin receptor 1 (GALR1). Spexin is implicated in various physiological processes, including energy homeostasis, nociception, and anxiety modulation. Role in Energy Homeostasis Spexin has been identified as an endogenous satiety-inducing peptide. It inhibits the uptake of long-chain fatty acids by adipocytes and reduces food consumption in diet-induced obese rodent models. Notably, spexin gene expression is significantly downregulated in the adipose tissue of obese individuals, suggesting a potential link between spexin levels and obesity. Anxiolytic Effects Beyond its metabolic functions, spexin exhibits anxiolytic properties. In vivo studies have demonstrated that administration of spexin leads to reduced anxiety-like behaviors in animal models, indicating its potential role in mood regulation. Reproductive Function Spexin has been shown to attenuate luteinizing hormone (LH) secretion in goldfish, indicating a possible involvement in reproductive endocrinology. This effect suggests that spexin may play a role in the regulation of reproductive hormones across different species. Therapeutic Potential Given its multifaceted roles, spexin is being explored as a therapeutic target for conditions such as obesity, anxiety disorders, and reproductive dysfunctions. The development of spexin-based agonists with increased stability has shown promising anxiolytic effects in preclinical studies, paving the way for potential clinical applications. Conclusion Spexin is a multifunctional neuropeptide with significant roles in regulating metabolism, mood, and reproductive functions. Ongoing research continues to elucidate its mechanisms of action and therapeutic potential, highlighting its importance in both physiological and pathological contexts.

Reference: Ma, A., Bai, J., He, M., & Wong, A. O. (2018). Spexin as a neuroendocrine signal with emerging functions. General and comparative endocrinology, 265, 90-96.