ACTH (11-24)

Product Name:ACTH (11-24)

Form:Acetate salt

Purity:95%

Storage:2-8 degree Celsius

Cas No:4237-93-8

Molar Mass:1652.1

Chemical Formula:C77H134N24O16

IUPAC Name:(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxylic acid

SMILES:CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCCN)N

InChIKey:WNXWTCYVIHOQAJ-IOSGZJLWSA-N

InChI: InChI=1S/C77H134N24O16/c1-44(2)60(97-67(108)56-26-17-39-99(56)72(113)49(82)20-7-11-33-78)69(110)89-43-59(103)90-50(21-8-12-34-79)63(104)91-51(22-9-13-35-80)64(105)92-53(24-15-37-87-76(83)84)65(106)94-54(25-16-38-88-77(85)86)73(114)100-40-18-27-57(100)68(109)98-62(46(5)6)70(111)93-52(23-10-14-36-81)66(107)96-61(45(3)4)71(112)95-55(42-47-29-31-48(102)32-30-47)74(115)101-41-19-28-58(101)75(116)117/h29-32,44-46,49-58,60-62,102H,7-28,33-43,78-82H2,1-6H3,(H,89,110)(H,90,103)(H,91,104)(H,92,105)(H,93,111)(H,94,106)(H,95,112)(H,96,107)(H,97,108)(H,98,109)(H,116,117)(H4,83,84,87)(H4,85,86,88)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,60-,61-,62-/m0/s1

Sequence:Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro

Application:

ACTH (11-24) is a bioactive peptide fragment derived from adrenocorticotropic hormone (ACTH), consisting of the sequence Glu-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Lys-Arg-Arg. While it lacks the N-terminal domain necessary for adrenal steroidogenesis, this fragment has been studied for its neuromodulatory, cognitive-enhancing, and immunoregulatory properties. Research suggests ACTH (11-24) may influence neurotransmitter signaling, memory function, and immune system regulation. It is widely used in studies on stress adaptation, neuroprotection, and inflammatory responses, with potential applications in Alzheimer’s disease, mood disorders, and immune-related conditions. Its structural properties make it valuable for peptide-receptor interaction and melanocortin system research.

Current Research:

Introduction
ACTH fragments, such as ACTH (11-24), are gaining interest in research due to their neuromodulatory and immunoregulatory effects. Unlike full-length ACTH (1-39), which stimulates adrenal corticosteroid secretion, C-terminal ACTH fragments have been associated with non-adrenal functions related to neurotransmitter regulation, cognitive processes, and immune modulation. ACTH (11-24) has been studied in neuroscience, immunology, and peptide metabolism research, particularly for its role in melanocortin receptor interactions.

Neurobiological and Cognitive Research
ACTH (11-24) has been investigated for its role in learning, memory, and cognitive enhancement. Studies suggest that it may:

Enhance cognitive function by influencing synaptic plasticity and neuropeptide signaling.
Regulate neurotransmitter systems, particularly dopaminergic and serotonergic pathways, which are crucial for cognition and mood regulation.
Protect against neurodegeneration, showing potential applications in Alzheimer’s and Parkinson’s disease research.
Studies in animal models of cognitive impairment have suggested that ACTH (11-24) improves memory retention and learning capacity, making it a candidate for age-related cognitive decline research.

Stress Adaptation and Neuropsychiatric Research
ACTH-derived peptides are known to modulate stress responses and influence HPA axis regulation. Research findings suggest that ACTH (11-24):

Modulates stress-related behaviors, influencing anxiety and emotional resilience.
May exhibit antidepressant-like effects, potentially useful for treating depression and PTSD.
Regulates the stress hormone response, potentially altering cortisol release patterns.
By acting on neuropeptide signaling pathways, ACTH (11-24) has been proposed as a potential therapeutic agent in neuropsychiatric disorders.

Immunomodulatory and Anti-Inflammatory Properties
Melanocortin peptides, including ACTH fragments, interact with immune cells, suggesting a role in immune regulation. Research indicates that ACTH (11-24):

Inhibits pro-inflammatory cytokine production, reducing levels of TNF-α, IL-6, and IL-1β.
Modulates immune cell activity, suggesting potential applications in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
May regulate neuroinflammation, providing potential benefits in neurodegenerative conditions.
These findings suggest that ACTH (11-24) could be explored as an anti-inflammatory and immune-regulating peptide.

Peptide Stability and Receptor Binding Studies
Since C-terminal ACTH fragments play a role in peptide metabolism and receptor interactions, ACTH (11-24) is commonly included in:

Melanocortin receptor (MC4R and MC5R) studies, which are linked to neuroprotection and immune responses.
Peptide degradation and bioavailability research, contributing to pharmacokinetic studies.
Peptide-based drug development, focusing on stabilized analogs for therapeutic use.
Understanding peptide-receptor interactions can provide insights into new drug designs for neurological and immune disorders.

Potential Therapeutic and Research Applications
Due to its cognitive, stress-regulating, and immunomodulatory properties, ACTH (11-24) is being explored in:

Cognitive enhancement therapies for dementia and age-related memory loss.
Neuroimmune and neuropsychiatric research, targeting stress-related disorders.
Anti-inflammatory and immune therapies, particularly for autoimmune and inflammatory diseases.
Conclusion
ACTH (11-24) is a bioactive ACTH fragment with potential applications in neurology, psychiatry, and immunology. While it does not activate adrenal corticosteroid release, its role in neurotransmission, stress response, and immune function makes it a valuable research tool. Ongoing studies continue to explore its therapeutic potential in cognitive decline, neuroinflammation, and stress-related disorders, contributing to peptide-based drug development and neuroimmune research.