ACTH (7-38), human

Product Name:ACTH (7-38), human

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Cas No:68563-24-6

Molar Mass:3659.2

Chemical Formula:C167H257N47O46

IUPAC Name:(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]acetyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]acetyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]pentanedioic acid

SMILES:C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC7=CNC8=CC=CC=C87)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC9=CC=CC=C9)N

InChIKey:ZKALIGRYJXFMNS-XBDDSDALSA-N

InChI:InChI=1S/C167H257N47O46/c1-87(2)75-113(150(245)200-112(164(259)260)59-63-131(227)228)203-153(248)120-48-31-73-213(120)162(257)117(77-95-37-16-13-17-38-95)205-138(233)93(11)188-142(237)107(56-60-128(221)222)192-137(232)92(10)189-152(247)119(86-215)207-148(243)109(58-62-130(225)226)197-151(246)116(81-132(229)230)202-147(242)108(57-61-129(223)224)193-136(231)91(9)187-125(218)83-184-141(236)115(80-124(173)217)204-154(249)121-49-32-74-214(121)163(258)118(78-96-52-54-98(216)55-53-96)206-159(254)134(89(5)6)208-149(244)104(43-22-26-66-170)198-158(253)135(90(7)8)210-156(251)123-51-34-72-212(123)161(256)111(47-30-70-182-167(178)179)199-145(240)106(46-29-69-181-166(176)177)196-144(239)103(42-21-25-65-169)195-143(238)102(41-20-24-64-168)190-126(219)85-186-157(252)133(88(3)4)209-155(250)122-50-33-71-211(122)160(255)110(44-23-27-67-171)191-127(220)84-185-140(235)114(79-97-82-183-101-40-19-18-39-99(97)101)201-146(241)105(45-28-68-180-165(174)175)194-139(234)100(172)76-94-35-14-12-15-36-94/h12-19,35-40,52-55,82,87-93,100,102-123,133-135,183,215-216H,20-34,41-51,56-81,83-86,168-172H2,1-11H3,(H2,173,217)(H,184,236)(H,185,235)(H,186,252)(H,187,218)(H,188,237)(H,189,247)(H,190,219)(H,191,220)(H,192,232)(H,193,231)(H,194,234)(H,195,238)(H,196,239)(H,197,246)(H,198,253)(H,199,240)(H,200,245)(H,201,241)(H,202,242)(H,203,248)(H,204,249)(H,205,233)(H,206,254)(H,207,243)(H,208,244)(H,209,250)(H,210,251)(H,221,222)(H,223,224)(H,225,226)(H,227,228)(H,229,230)(H,259,260)(H4,174,175,180)(H4,176,177,181)(H4,178,179,182)/t91-,92-,93-,100-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,133-,134-,135-/m0/s1

Sequence:Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu

Application:ACTH (7-38), human is a synthetic fragment of adrenocorticotropic hormone (ACTH) that lacks the first six amino acids but retains the core sequence essential for melanocortin receptor interactions. Unlike full-length ACTH (1-39), this truncated form exhibits modified receptor affinity and biological activity, making it a useful tool in adrenal function, neuroendocrine signaling, and inflammatory regulation studies. ACTH (7-38) is widely utilized in melanocortin receptor research, immune modulation studies, and stress-related investigations. It plays a role in understanding glucocorticoid regulation, neuropeptide signaling, and melanocortin-based therapeutic development, particularly for endocrine, neurological, and inflammatory disorders.

Current Research:

Introduction
Adrenocorticotropic hormone (ACTH) is a key component of the hypothalamic-pituitary-adrenal (HPA) axis, regulating adrenal corticosteroid production via melanocortin receptor (MC2R) activation. ACTH (7-38) is a modified peptide fragment that excludes the first six amino acids of full-length ACTH (1-39), altering its receptor binding profile and bioactivity. This fragment is valuable for research on melanocortin signaling, adrenal regulation, immune modulation, and neuroendocrine function.

Endocrine and Adrenal Research
ACTH (7-38) interacts with melanocortin receptors, particularly MC2R in the adrenal cortex, but exhibits differences in receptor activation and steroidogenesis compared to full-length ACTH. This makes it a key research tool for investigating:

Adrenal insufficiency and glucocorticoid regulation (e.g., Addison’s disease and Cushing’s syndrome).
Selective receptor-ligand interactions for understanding melanocortin receptor pharmacology.
ACTH analog development, particularly for synthetic hormone therapies targeting adrenal function.
Research suggests that truncated ACTH fragments may act as partial agonists or antagonists, influencing cortisol production differently than full-length ACTH.

Neuroendocrine and Stress Response Research
ACTH fragments, including ACTH (7-38), have been studied for their role in HPA axis regulation and stress adaptation. Research explores their influence on:

Neuropeptide signaling and stress-induced hormonal responses.
Cognition and mood regulation, particularly in depression and anxiety disorders.
Neurological conditions linked to stress, including PTSD and neurodegenerative diseases.
Studies indicate that ACTH-derived peptides may interact with melanocortin receptors in the brain, affecting dopaminergic and serotonergic pathways involved in mood and behavior regulation.

Immunomodulatory and Anti-Inflammatory Properties
Melanocortin peptides have immune-modulating functions, with ACTH fragments influencing:

Cytokine production, regulating inflammation in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Neuroinflammation, with potential implications in Alzheimer’s disease and multiple sclerosis.
Immune response balancing, potentially reducing systemic inflammation and cytokine storms.
ACTH (7-38) is used in studies investigating melanocortin-based immune regulation, contributing to the development of anti-inflammatory peptide therapeutics.

Potential Therapeutic Applications
Due to its modified receptor activity, ACTH (7-38) is being explored for:

Selective melanocortin receptor modulation in adrenal disorders.
Stress-related neuropsychiatric conditions, including mood and anxiety disorders.
Inflammatory and autoimmune disease treatments, leveraging melanocortin-based immune suppression and neuroprotection.
Conclusion
ACTH (7-38), human, is a truncated ACTH fragment with unique receptor interactions influencing adrenal, neuroendocrine, and immune functions. Its selective activity provides insights into melanocortin receptor modulation, making it a valuable research tool for endocrine disorders, stress-related conditions, and inflammatory diseases. Ongoing studies continue to explore its therapeutic potential in adrenal regulation, neuroprotection, and immune modulation.