[Expand product categories]

Receptor Ligand Peptides

Precision Modulators of Receptor Binding and Signal Transduction

Overview

Receptor ligand peptides are bioactive molecules that specifically bind to cell surface receptors, influencing receptor activation, inhibition, or modulation. These peptides play a central role in cellular signaling by triggering or blocking signaling pathways that regulate various cellular processes, including proliferation, differentiation, immune response, and metabolism. By mimicking or inhibiting endogenous ligands, receptor ligand peptides are widely used in research focused on understanding receptor function, studying signaling networks, and developing therapeutic strategies targeting receptor-based pathways.

Biological Function & Mechanisms

Receptor ligand peptides exert their effects by interacting with specific cell surface receptors, which include G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), and cytokine receptors. The peptides act as either agonists or antagonists, modulating receptor-mediated signaling pathways:
  • Agonists activate receptors, mimicking the action of natural ligands and stimulating downstream signaling
  • Antagonists block receptor activation, preventing the binding of endogenous ligands and inhibiting signaling
  • Partial agonists exert a weaker signaling effect compared to full agonists
  • Allosteric modulators alter receptor function without directly competing with the ligand binding site
Through these mechanisms, receptor ligand peptides regulate a wide array of signaling pathways such as MAPK/ERK, PI3K/AKT, cAMP, and JAK/STAT, all of which influence cellular behavior in both normal and disease contexts.

Default Ranking Price By Date
(D-Lys16)-ACTH (1-24) human, bovine, mouse, ovi...

(D-Lys16)-ACTH (1-24) human, bovine, mouse, ovine, porcine, rabbit, rat

$985.00
Details
Add Inquiry
(DSer1)-ACTH (1-24) (human, bovine, mouse, ovin...

(DSer1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)

$985.00
Details
Add Inquiry
(p-Iodo-Phe7)-ACTH (4-10)

(p-Iodo-Phe7)-ACTH (4-10)

$495.00
Details
Add Inquiry
(Tyr15)-ACTH (7-15)

(Tyr15)-ACTH (7-15)

$495.00
Details
Add Inquiry
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPa...

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide

Details
Add Inquiry
[D-Trp8]-γ-MSH

[D-Trp8]-γ-MSH

Details
Add Inquiry
[Phe2,Nle4] ACTH (1-24), human

[Phe2,Nle4] ACTH (1-24), human

$885.00
Details
Add Inquiry
[Tyr1] Adipokinetic Hormone, locust

[Tyr1] Adipokinetic Hormone, locust

$395.00
Details
Add Inquiry
26RFa

26RFa

Details
Add Inquiry
Abaloparatide

Abaloparatide

$445.00
Details
Add Inquiry
Abarelix

Abarelix

$248.00
Details
Add Inquiry
Ac9-25

Ac9-25

Details
Add Inquiry

Research Context & Significance

Receptor ligand peptides are indispensable in both basic and applied research due to their ability to precisely regulate receptor activity. Dysregulation of receptor signaling is implicated in a wide range of diseases, including cancer, autoimmune disorders, and metabolic diseases. Receptor ligand peptides are extensively used in:
  • Cancer research, where receptor signaling drives tumor growth, metastasis, and resistance to treatment
  • Immunology, where receptor-mediated signaling regulates immune cell activation, differentiation, and cytokine production
  • Neurobiology, where peptides modulate neurotransmission and neuronal communication
  • Drug discovery, where receptor-targeted peptides serve as leads for developing novel therapeutics
Their high specificity for receptor types makes them crucial for dissecting signaling pathways and developing targeted therapies.

Key Subcategories

GPCR Ligand Peptides Peptides that interact with G protein-coupled receptors, involved in numerous physiological processes, from neurotransmission to immune response RTK Ligand Peptides Peptides targeting receptor tyrosine kinases, regulating processes such as cell growth, differentiation, and metabolism Cytokine Receptor Ligands Peptides that interact with cytokine receptors, modulating immune and inflammatory responses Ion Channel Ligand Peptides Peptides that modulate ion channel function, involved in neurotransmission and cellular excitability

Applications

Receptor Biology Research Studying receptor activation, downstream signaling, and receptor-mediated gene expression Cancer Research Investigating receptor-driven pathways that contribute to tumorigenesis, metastasis, and drug resistance Immunology and Inflammation Exploring how receptor signaling regulates immune cell activation, cytokine production, and inflammatory responses Neuroscience Investigating how peptides modulate neurotransmission, synaptic plasticity, and neural communication Drug Discovery & Target Validation Screening peptides to identify potential drug leads and validate receptor-based therapeutic targets

Representative Peptides

Commonly used receptor ligand peptides include:
  • Angiotensin II – a peptide that regulates blood pressure and fluid balance through the angiotensin receptor
  • GLP-1 – a peptide involved in glucose homeostasis through its action on the GLP-1 receptor
  • Epidermal Growth Factor (EGF) – a peptide that stimulates cell proliferation via the EGFR (epidermal growth factor receptor)
  • Bradykinin – a peptide that regulates vasodilation and inflammatory responses through its interaction with the bradykinin receptor
  • Cytokine-based peptides – such as IL-6 or TNF-α peptides, involved in immune signaling and inflammation
These peptides are widely studied for their role in regulating receptor activity and signaling pathways in various biological contexts.

Why Choose LinkPeptide

  • Extensive collection of receptor-targeting peptides with high specificity for various receptor types
  • Custom peptide synthesis for receptor-specific applications and pathway-focused studies
  • Reliable analytical validation to ensure reproducibility and accuracy across experiments
  • Flexible applications in drug discovery, functional genomics, and disease modeling

Related Categories

Cell Signaling Peptides → for downstream pathway modulation and signal transduction studies Immunoregulatory Peptides → for immune receptor and cytokine pathway research Neuropeptides → for receptor-mediated signaling in the central nervous system Peptide Inhibitors → for selective suppression of receptor activity Growth Factors & Regenerative Peptides → for receptor-driven cellular growth and regeneration
Add InquiryUp to 12 can be added
Start Inquiry Clear All

Get a Quote

Get a Quote

*
*
*

unit

Submitting....
Successfu！
Submission failed! Please try again later.
Email error!
Phone error!

No products in the cart.