[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] – hPancreatic Polypeptide

Product Name:[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide

CAS No:313988-89-5

Purity:95%

Molar Mass:4208

Chemical Formula:C183H281N57O54S2

Storage:Store at -20 degrees Celsius

Sequence:GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY

Application:

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a synthetic analog of human pancreatic polypeptide (hPP) with multiple modifications designed to enhance stability, receptor selectivity, and biological activity. This peptide features a cyclic structure in the first seven amino acids (cPP1-7), a sequence from neuropeptide Y (NPY19-23), and substitutions at positions 31, 32, and 34 with alanine, α-aminoisobutyric acid (Aib), and glutamine, respectively. These modifications improve receptor binding affinity and resistance to enzymatic degradation. The analog is widely used in research to explore the roles of pancreatic polypeptide in appetite regulation, energy metabolism, and potential therapeutic applications for metabolic disorders.

Current Research:

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a synthetic analog of human pancreatic polypeptide (hPP) engineered with specific modifications to enhance its structural stability and functional selectivity. These modifications include: cPP1-7: Replacement of the first seven amino acids with those of the highly conserved carboxy-terminal fragment of bovine pancreatic polypeptide (cPP). NPY19-23: Incorporation of residues 19-23 from neuropeptide Y (NPY). Ala31, Aib32: Substitutions at positions 31 and 32 to alanine and ??-aminoisobutyric acid (Aib), respectively, to increase structural rigidity. Gln34: Addition of glutamine at position 34. Structural and Functional Insights Receptor Binding: The analog exhibits high affinity for Y4 and Y1 receptors, which are G protein-coupled receptors involved in regulating appetite, energy balance, and digestive functions. Stability: The incorporation of Aib and the modification of the N-terminal region increase resistance to enzymatic degradation, prolonging the peptide's half-life in biological systems. Bioactivity: This analog retains the biological activity of native hPP while offering enhanced receptor specificity and stability, making it a useful tool for research and therapeutic exploration. Research Applications Appetite Regulation: Used to study the role of pancreatic polypeptide and its analogs in suppressing appetite and regulating food intake. Aids in exploring the potential of Y4 and Y1 receptor agonists as anti-obesity treatments. Metabolic Studies: Investigates the impact of pancreatic polypeptide signaling on glucose homeostasis, lipid metabolism, and energy expenditure. Offers insights into therapeutic strategies for metabolic disorders like diabetes. Receptor Pharmacology: Serves as a probe for studying Y4 and Y1 receptor signaling pathways and interactions with other neuropeptides like NPY and PYY. Drug Development: Provides a scaffold for developing long-acting peptide therapeutics targeting appetite and metabolism. Handling and Storage Form: Typically supplied as a lyophilized powder. Storage: Store at -20 degrees Celsius in a desiccated environment to ensure stability. Reconstitution: Reconstitute in sterile water or appropriate buffer for experimental applications. Conclusion [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a valuable analog of human pancreatic polypeptide, designed for enhanced stability and receptor specificity. Its use in research provides critical insights into appetite regulation, energy balance, and potential therapeutic interventions for metabolic disorders.

Reference:

Morales-Medina, J. C., Dominguez-Lopez, S., Gobbi, G., Beck-Sickinger, A. G., & Quirion, R. (2012). The selective neuropeptide Y Y5 agonist [cPP1–7, NPY19–23, Ala31, Aib32, Gln34] hPP differently modulates emotional processes and body weight in the rat. Behavioural brain research, 233(2), 298-304.