(Tyr15)-ACTH (7-15)

Product Name:(Tyr15)-ACTH (7-15)

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Molar Mass:1109.3

Chemical Formula:C55H76N14O11

Sequence:Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Tyr

Application:

(Tyr¹⁵)-ACTH (7-15) is a synthetic ACTH fragment modified with a tyrosine substitution at position 15. This short bioactive peptide retains a core sequence involved in melanocortin receptor interactions, making it relevant in neuroendocrine, cognitive, and immune research. Studies suggest that this fragment may influence neurotransmitter regulation, stress adaptation, and immune modulation. Due to its structural modification, (Tyr¹⁵)-ACTH (7-15) is used in research on peptide stability, receptor binding specificity, and neuropeptide function. It is particularly valuable for investigating cognition, neuroprotection, and immune signaling, with potential applications in neurodegenerative diseases, stress disorders, and inflammation control.

Current Research:

Introduction
(Tyr¹⁵)-ACTH (7-15) is a modified ACTH peptide fragment that includes a tyrosine substitution at position 15, potentially altering its binding affinity, stability, and bioactivity. This fragment lacks the N-terminal sequence required for adrenal steroidogenesis but retains structural regions involved in melanocortin receptor interactions. Research on ACTH-derived peptides suggests that certain fragments play roles in neuroprotection, immune regulation, and neurotransmitter modulation, making (Tyr¹⁵)-ACTH (7-15) a target of interest in neurobiology, endocrinology, and immunology.

Neurobiological and Cognitive Research
ACTH fragments are widely studied for their neuromodulatory properties, with evidence suggesting they influence memory, learning, and neurotransmitter regulation. Research on (Tyr¹⁵)-ACTH (7-15) includes:

Neurotransmitter regulation, particularly in the dopaminergic and serotonergic systems, which are key to mood, cognition, and stress response.
Potential cognitive-enhancing effects, with implications in memory retention and neuroplasticity.
Neuroprotective properties, making it relevant for studies in Alzheimer’s disease, Parkinson’s disease, and cognitive impairment models.
Given its structural modifications, (Tyr¹⁵)-ACTH (7-15) is also used in receptor-binding research, helping scientists explore melanocortin system signaling beyond adrenal stimulation.

Stress Regulation and Mood Disorders
ACTH-derived peptides influence stress adaptation through interactions with the HPA axis and central neurotransmitter systems. Studies on (Tyr¹⁵)-ACTH (7-15) explore:

Potential effects on stress resilience, making it relevant for anxiety, depression, and PTSD research.
Regulation of neuropeptide pathways, affecting emotional regulation and behavioral adaptation to stress.
This research aligns with studies on melanocortin receptor-mediated neuromodulation, which plays a role in mood and anxiety disorders.

Immunomodulatory and Anti-Inflammatory Effects
ACTH fragments have been found to regulate immune responses, with some peptides acting as immune suppressors or anti-inflammatory agents. (Tyr¹⁵)-ACTH (7-15) is investigated for:

Its ability to influence cytokine production, which may have implications in inflammatory and autoimmune diseases.
Neuroimmune regulation, contributing to research on multiple sclerosis, neuroinflammation, and chronic inflammatory conditions.
Potential receptor-selective immune modulation, making it useful for developing melanocortin-based immune therapies.
Peptide Stability and Receptor Binding Studies
Due to its tyrosine substitution, (Tyr¹⁵)-ACTH (7-15) is also a subject of research in:

Peptide degradation and metabolic stability studies, which are important for pharmacokinetics and peptide drug development.
Receptor binding affinity research, particularly regarding melanocortin receptor subtypes (MC4R and MC5R).
These findings are valuable in designing synthetic peptide-based therapeutics with improved stability and selectivity.

Potential Research and Therapeutic Applications
Given its neuroprotective, immune-regulating, and receptor-interacting properties, (Tyr¹⁵)-ACTH (7-15) is studied for:

Cognitive enhancement therapies, particularly for memory loss and neurodegeneration.
Neuroimmune and neuropsychiatric research, focusing on stress adaptation and neuroinflammatory diseases.
Peptide-based drug development, targeting melanocortin receptor modulation and immune regulation.
Conclusion
(Tyr¹⁵)-ACTH (7-15) is a structurally modified ACTH fragment with potential applications in neuroprotection, stress regulation, and immune function. Its altered receptor-binding properties make it a valuable tool for neuroendocrine and immunology research, particularly in cognitive decline, neuroinflammation, and peptide pharmacology. Ongoing studies continue to investigate its therapeutic potential and receptor specificity in neurological and inflammatory disorders.