Product Name:ANQ 11125
CAS No:153966-48-4
Purity:95%
Molar Mass:1761.03
Chemical Formula:C86H125N19O21
Storage:Store at -20 degrees Celsius
Sequence:FVFIFTYGELQRLQ
Target:motilin
Application:
ANQ 11125 is a peptide related to motilin, a gastrointestinal hormone that stimulates gastric motility and plays a crucial role in the regulation of digestive processes. Motilin is primarily responsible for inducing the migrating motor complex (MMC), which helps move food through the digestive tract during fasting. ANQ 11125, by interacting with motilin receptors, may influence gut motility and has potential applications in research related to gastrointestinal disorders, motility dysfunction, and treatments for conditions like gastroparesis. Its ability to modulate the motilin pathway makes it a useful tool in understanding digestive health and developing therapeutic strategies.
Current Research:
ANQ 11125 (CAS: 153966-48-4), also known as [Phe³,Leu¹³]porcine motilin, is a synthetic peptide analog of porcine motilin. This 14-amino acid peptide selectively inhibits motilin receptor activity, with a dissociation constant (pKₐ) of 8.24. Its high specificity makes it an invaluable tool for studying gastrointestinal motility and motilin receptor pharmacology.
Mechanism of Action
Motilin is a gastrointestinal peptide hormone that stimulates smooth muscle contraction in the upper gastrointestinal tract, playing a key role in regulating gastric motility. ANQ 11125 competitively binds to motilin receptors, effectively blocking the action of endogenous motilin. This antagonism prevents motilin-mediated stimulation of smooth muscle contraction. Studies demonstrate that ANQ 11125 inhibits motilide-induced contractions in isolated rabbit duodenum without interfering with responses to other agonists, such as acetylcholine or serotonin. This receptor specificity highlights its utility in delineating motilin-specific pathways.
Research Applications
Gastrointestinal Motility: ANQ 11125 is widely used to explore motilin's role in coordinating gastrointestinal movements during the fasting state. It helps dissect the interplay between motilin receptors and other gastrointestinal regulators.
Pharmacological Studies: As a selective antagonist, ANQ 11125 aids in identifying receptor-specific effects of motilin analogs or motilides, providing insights into therapeutic development for motility disorders.
Motility Disorders: Research involving ANQ 11125 contributes to understanding conditions such as gastroparesis, where abnormal motilin signaling may disrupt gastric emptying.
Conclusion
ANQ 11125 is a selective and potent motilin receptor antagonist, offering critical insights into gastrointestinal motility regulation. Its utility in preclinical studies continues to advance our understanding of motilin’s physiological role and its implications for treating motility disorders.
Reference:
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