LEIUROTOXIN I [R7]-

Product Name:LEIUROTOXIN I [R7]-

CAS No:116235-63-3 (Parent)

Purity:95%

Molar Mass:3449

Chemical Formula:C142H237N45O39S7

Storage:Store at -20 degrees Celsius

Sequence:Ala-Phe-Cys3-Asn-Leu-Arg-Met-Cys8-Gln-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21-Ile-Gly-Asp-Lys-Cys26-Glu-Cys28-Val-Lys-His-NH2

Target:SK channels blocker

Application:

Leiurotoxin I [R7]- is a modified peptide toxin derived from the venom of the scorpion Leiurus quinquestriatus. This variant of Leiurotoxin I, where the seventh amino acid has been substituted with arginine (R7), is utilized in neurobiological research for its ability to target and block small conductance calcium-activated potassium (SK) channels. This specific modification enhances its utility in studying the physiological and pathological roles of SK channels, particularly in the context of neuronal excitability, signal transduction, and cellular calcium homeostasis. Leiurotoxin I [R7]- is essential for probing the intricacies of ion channel function and exploring therapeutic avenues for conditions like epilepsy, neurodegenerative diseases, and immune disorders.

Current Research:

Leiurotoxin I, also known as scyllatoxin, is a 31-amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus. It functions as a potent inhibitor of small-conductance calcium-activated potassium (SK) channels, thereby modulating neuronal excitability and synaptic transmission. Structurally, leiurotoxin I is stabilized by three disulfide bridges, which are crucial for maintaining its bioactive conformation. The substitution of Met7 with Arg7 is designed to optimize interactions with the target ion channels, potentially improving both potency and selectivity. In neurophysiological research, [R7]-leiurotoxin I serves as a valuable tool for probing the functional roles of SK channels in various tissues. By selectively inhibiting these channels, researchers can dissect their contributions to cellular processes such as action potential repolarization and neurotransmitter release. This specificity is particularly beneficial in studies aiming to understand the pathophysiology of conditions like epilepsy, where altered SK channel activity is implicated. Furthermore, the enhanced properties of [R7]-leiurotoxin I make it a promising candidate for the development of therapeutic agents targeting SK channels. Its ability to modulate channel activity with high specificity offers potential avenues for treating disorders associated with dysregulated potassium conductance. In summary, [R7]-leiurotoxin I is a modified peptide toxin that provides significant insights into SK channel function and holds potential for therapeutic applications in diseases linked to potassium channel dysfunction.

Reference:

Sabatier, J. M., Fremont, V., Mabrouk, K., Crest, M., Darbon, H., Rochat, H., … & Martin‐Eauclaire, M. F. (1994). Leiurotoxin I, a scorpion toxin specific for Ca2+‐activated K+ channels Structure‐activity analysis using synthetic analogs. International Journal of Peptide and Protein Research, 43(5), 486-495.