BA 1

Product Name:BA 1

CAS No:183241-31-8

Purity:95%

Molar Mass:1133.3

Chemical Formula:C57H76N14O11

Storage:Store at -20 degrees Celsius

Sequence:{d-Tyr}-QWAV-{Bal}-HF-{Nle}-NH2

Target:BRS3

Application:

BA 1 is related to BRS3 (Bombesin Receptor Subtype 3), a G protein-coupled receptor involved in regulating energy metabolism, food intake, and body weight. BRS3 is primarily expressed in the central nervous system and plays a role in metabolic regulation. Peptides like BA 1 that target BRS3 are of interest in research for their potential to modulate metabolic disorders, including obesity and diabetes. By influencing BRS3 activity, BA 1 could help explore therapeutic approaches for conditions where metabolic control is disrupted.

Current Research:

BA 1 (CAS: 183241-31-8) is a potent agonist of the bombesin receptor family, which includes three subtypes: BB1 (neuromedin B receptor, NMBR), BB2 (gastrin-releasing peptide receptor, GRPR), and BB3 (bombesin receptor subtype-3, BRS3). It binds to these receptors with high affinity, exhibiting IC₅₀ values of 0.26 nM for BB1, 1.55 nM for BB2, and 2.52 nM for BB3.

Biological Activity

BA 1 has been shown to enhance glucose transport in primary myocytes derived from obese and diabetic models, indicating its potential role in modulating glucose metabolism. Additionally, it stimulates the proliferation of NCI-H1299 lung cancer cells in vitro, suggesting its involvement in cell growth and proliferation pathways.

Chemical Properties

The molecular formula of BA 1 is C₅₇H₇₆N₁₄O₁₁, with a molecular weight of 1133.32 g/mol. Its structure includes a sequence of amino acids: D-Tyr-Gln-Trp-Ala-Val-β-Ala-His-Phe-Nle-NH₂, where D-Tyr is D-tyrosine, β-Ala is beta-alanine, and Nle is norleucine.

Research Applications

Due to its high affinity and specificity for bombesin receptors, BA 1 is utilized in research to study the physiological and pathological roles of these receptors. Its effects on glucose transport and cell proliferation make it a valuable tool in investigating metabolic disorders and cancer biology.

Storage and Handling

BA 1 should be stored at -20°C to maintain its stability. It is typically supplied as a solid and should be handled in accordance with standard laboratory safety protocols.

Conclusion

BA 1 serves as a significant compound in biomedical research, offering insights into bombesin receptor functions and their implications in metabolic and proliferative processes. Its potent agonistic activity makes it a valuable tool for exploring therapeutic targets related to these receptors.

Reference:

Moody, T. W., Mantey, S. A., Moreno, P., Nakamura, T., Lacivita, E., Leopoldo, M., & Jensen, R. T. (2015). ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides, 64, 55-61.