Bombesin

Product Name: Bombesin

CAS No: 31362-50-2

Purity: 95%

Molar Mass: 1619.9

Chemical Formula: C71H110N24O18S

Synonyms: Bombesin 14

Storage: Store at -20 degrees Celsius

Sequence: XQRLGNQWAVGHLM

Application:

Bombesin is a peptide originally isolated from frog skin that acts as a potent agonist for the gastrin-releasing peptide (GRP) receptors. It stimulates the release of gastrin, cholecystokinin, and other gastrointestinal hormones, leading to increased digestive enzyme secretion and smooth muscle contraction. Bombesin's role in regulating gastrointestinal motility and hormone release makes it a valuable tool in studying digestive processes and neuroendocrine signaling. Additionally, due to its expression in various cancers, Bombesin is being explored as a target for diagnostic imaging and therapeutic interventions in oncology, particularly in neuroendocrine and small cell lung cancers.

Current Research:

Bombesin, a 14-amino-acid peptide originally isolated from amphibian skin, has become a focal point in drug discovery due to its role in modulating a variety of physiological processes. A homolog to mammalian gastrin-releasing peptide (GRP), bombesin interacts with a family of G protein-coupled receptors (GPCRs) including GRP receptor (GRPR), neuromedin B receptor (NMBR), and bombesin receptor subtype 3 (BB3). These receptors are implicated in diverse biological functions, including regulation of gastrointestinal motility, thermoregulation, and cellular proliferation.

In oncology, bombesin has garnered significant attention as a diagnostic and therapeutic target due to its overexpression in various cancers, such as prostate, breast, lung, and gastrointestinal cancers. Bombesin analogs conjugated with imaging agents or cytotoxic moieties have shown promise in targeted imaging and therapy. Radiolabeled bombesin analogs, for example, are being explored for their potential in positron emission tomography (PET) imaging, enabling the precise localization of GRPR-positive tumors.

Beyond cancer research, bombesin’s role in metabolic regulation and central nervous system (CNS) signaling offers additional avenues for therapeutic exploration. Studies suggest that bombesin receptor agonists and antagonists may modulate feeding behavior, stress responses, and thermogenesis, positioning bombesin-related pathways as potential targets for obesity and metabolic syndrome treatments.

Research into bombesin receptor dynamics and structure-function relationships is further expanding its therapeutic potential. High-affinity bombesin analogs and antagonists are being developed to enhance receptor selectivity and improve therapeutic outcomes, particularly in minimizing off-target effects.

For researchers in drug discovery, bombesin serves as a versatile molecule bridging oncology, metabolic disorders, and CNS research. Its role in advancing targeted diagnostics and therapeutics highlights the potential of peptide-based approaches in addressing complex diseases.

Reference:

Ramos-Álvarez, I., Moreno, P., Mantey, S. A., Nakamura, T., Nuche-Berenguer, B., Moody, T. W., … & Jensen, R. T. (2015). Insights into bombesin receptors and ligands: highlighting recent advances. Peptides, 72, 128-144.