Cyclosomatostatin

Product Name: Cyclosomatostatin

CAS No: 84211-54-1

Purity: 95%

Molar Mass: 780.0

Chemical Formula: C44H57N7O6

Storage: Store at -20 degrees Celsius

Sequence: FWKT

Target: sst

Application:

Cyclosomatostatin is a cyclic peptide analog of somatostatin, a hormone that inhibits the release of various secondary hormones. By binding to somatostatin receptors, cyclosomatostatin effectively reduces the secretion of growth hormone, insulin, and glucagon. This peptide is primarily used in endocrinological research to study hormone regulation and its effects on various physiological processes. It is also valuable in cancer research, particularly in tumors that are hormone-sensitive, and in the development of therapies for conditions like acromegaly, diabetes, and gastrointestinal disorders.

Current Research:

Cyclosomatostatin is a synthetic cyclic analog of somatostatin, a regulatory peptide known for its wide range of biological functions, including inhibition of hormone secretion, modulation of neurotransmission, and cell proliferation. Unlike somatostatin, which acts as an agonist for somatostatin receptors (SSTRs), cyclosomatostatin exhibits non-selective antagonistic properties, making it a valuable research tool for studying somatostatin receptor signaling. This peptide interacts with multiple SSTR subtypes (SSTR1-CSSTR5), effectively blocking the actions of endogenous somatostatin. Its non-selectivity allows for the investigation of broad somatostatin-related pathways, particularly in endocrine and neuroendocrine systems. Studies using cyclosomatostatin have provided insights into the regulation of growth hormone, insulin, and glucagon secretion, offering potential therapeutic implications in metabolic diseases such as diabetes mellitus. In oncology research, cyclosomatostatin has been used to explore the role of somatostatin receptors in tumor growth and angiogenesis. By inhibiting receptor-mediated signaling, it has facilitated the understanding of SSTR contributions to cancer progression, particularly in neuroendocrine tumors. Additionally, it serves as a reference compound in the development of selective somatostatin receptor antagonists, which are being investigated for their therapeutic potential in various cancers. Cyclosomatostatin also plays a critical role in neuroscience research, where it has been employed to study the modulatory effects of somatostatin on neurotransmission, pain perception, and neurodegenerative processes. Its application in animal models has contributed to understanding how somatostatin receptor inhibition affects central nervous system functions. In summary, cyclosomatostatin is a key research tool for exploring somatostatin receptor signaling across multiple biological systems. Its non-selective antagonistic properties provide a foundation for understanding receptor-mediated mechanisms and developing targeted therapies in endocrinology, oncology, and neuroscience.

Reference:

Rai, U., Thrimawithana, T. R., Valery, C., & Young, S. A. (2015). Therapeutic uses of somatostatin and its analogues: current view and potential applications. Pharmacology & therapeutics, 152, 98-110.