Cys-beta-Amyloid (1-40)

Product Name: Cys-beta-Amyloid (1-40)

Sequence One Letter Code: CDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

Sequence Three Letter Code: H-Cys-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

Cas No: 208266-35-7

Chemical Formula:C197H300N54O59S2

Molecular Weight: 4433

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC6=CNC=N6)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC7=CC=CC=C7)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)N

IUPAC: (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoic acid

INCHIKEY: IKZJNEBQGQZMNN-HQPIFIABSA-N

INCHI:

InChI=1S/C197H300N54O59S2/c1-25-103(19)160(191(304)214-87-145(260)221-125(67-95(3)4)177(290)231-124(62-66-312-24)174(287)245-154(97(7)8)189(302)212-83-142(257)209-84-147(262)244-156(99(11)12)194(307)249-159(102(17)18)196(309)310)251-195(308)161(104(20)26-2)250-164(277)105(21)218-143(258)85-210-166(279)117(47-36-38-63-198)226-184(297)134(76-141(202)256)238-188(301)139(90-253)223-146(261)88-213-190(303)155(98(9)10)246-187(300)137(79-153(273)274)239-172(285)122(56-60-149(265)266)225-162(275)106(22)219-175(288)128(69-108-41-30-27-31-42-108)235-180(293)130(71-110-45-34-29-35-46-110)241-192(305)158(101(15)16)248-186(299)126(68-96(5)6)233-168(281)118(48-37-39-64-199)227-170(283)120(54-58-140(201)255)229-181(294)131(73-112-80-205-92-215-112)237-183(296)133(75-114-82-207-94-217-114)242-193(306)157(100(13)14)247-173(286)123(57-61-150(267)268)230-178(291)127(72-111-50-52-115(254)53-51-111)222-144(259)86-211-167(280)138(89-252)243-185(298)136(78-152(271)272)240-182(295)132(74-113-81-206-93-216-113)236-169(282)119(49-40-65-208-197(203)204)228-179(292)129(70-109-43-32-28-33-44-109)234-171(284)121(55-59-148(263)264)224-163(276)107(23)220-176(289)135(77-151(269)270)232-165(278)116(200)91-311/h27-35,41-46,50-53,80-82,92-107,116-139,154-161,252-254,311H,25-26,36-40,47-49,54-79,83-91,198-200H2,1-24H3,(H2,201,255)(H2,202,256)(H,205,215)(H,206,216)(H,207,217)(H,209,257)(H,210,279)(H,211,280)(H,212,302)(H,213,303)(H,214,304)(H,218,258)(H,219,288)(H,220,289)(H,221,260)(H,222,259)(H,223,261)(H,224,276)(H,225,275)(H,226,297)(H,227,283)(H,228,292)(H,229,294)(H,230,291)(H,231,290)(H,232,278)(H,233,281)(H,234,284)(H,235,293)(H,236,282)(H,237,296)(H,238,301)(H,239,285)(H,240,295)(H,241,305)(H,242,306)(H,243,298)(H,244,262)(H,245,287)(H,246,300)(H,247,286)(H,248,299)(H,249,307)(H,250,277)(H,251,308)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H,273,274)(H,309,310)(H4,203,204,208)/t103-,104-,105-,106-,107-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,154-,155-,156-,157-,158-,159-,160-,161-/m0/s1

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Cys-Aβ (1–40) is a cysteine-containing mutant variant of amyloid-β (1–40), one of the major peptide species associated with amyloid plaque deposition in Alzheimer’s disease. Together with Aβ (1–42), Aβ (1–40) undergoes aggregation and fibril formation, contributing to amyloid pathology and neurodegenerative disease mechanisms. The introduced cysteine residue enables site-specific conjugation, labeling, and immobilization, making this peptide useful for structural, biochemical, and biophysical studies. Cys-Aβ (1–40) is widely used in amyloid aggregation research, inhibitor screening, peptide assembly analysis, and mechanistic investigations of plaque formation.