GSK3 Substrate, a, b subunit [RAAVPPSPSLSRHSSPHQSEDEEE]

Product Name: GSK3 Substrate, a, b subunit [RAAVPPSPSLSRHSSPHQSEDEEE]

Sequence One Letter Code: RAAVPPSPSLSRHSSPHQSEDEEE

Sequence Three Letter Code: H-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-Ser-Glu-Asp-Glu-Glu-Glu-OH

Chemical Formula:C108H169N35O42

Molecular Weight: 2629.9

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: mouse

Conjugation: Unconjugated

Code Nacres: NA.26

Application: GSK3 Substrate Peptide is a synthetic peptide substrate designed for glycogen synthase kinase-3 activity assays. It is phosphorylated by both GSK3α and GSK3β isoforms, providing a reliable tool for measuring GSK3-mediated phosphorylation. GSK3 is a key serine/threonine kinase involved in glycogen metabolism, Wnt signaling, neuronal function, inflammation, and cell regulation. Dysregulated GSK3 activity has been linked to neurodegenerative disorders, cancer, and diabetes. This peptide is widely used in kinase profiling, inhibitor screening, enzyme kinetics, and mechanistic studies of GSK3 signaling pathways in cellular and biochemical research.