[Lys(Ac)382]-p53 (372-389), human, biotin labeled

Product Name: [Lys(Ac)382]-p53 (372-389), human, biotin labeled

Sequence One Letter Code: Biotin-LC-KKGQSTSRHK-K(Ac)-LMFKTEG

Sequence Three Letter Code: Biotin-LC-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys(Ac)-Leu-Met-Phe-Lys-Thr-Glu-Gly-OH

Molecular Weight: 2473

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Lys(Ac)382]-p53 (372–389)-Biotin is a synthetic peptide derived from residues 372–389 of the human p53 tumor suppressor protein and acetylated at lysine 382. This modification is critical for p53 stabilization and transcriptional activity after DNA damage. Acetylation at K382 reduces MDM2-mediated ubiquitination, increasing p53 half-life and enhancing its regulatory function. The peptide is biotinylated through an N-terminal linker for affinity-based assays. [Lys(Ac)382]-p53 (372–389)-Biotin is widely used in cancer research to study p53 post-translational regulation, protein–protein interactions, DNA damage signaling, and modification-dependent tumor suppressor mechanisms.