[Lys(Me2)4]-Histone H3 (1-21)-GGK(Biotin)

Product Name: [Lys(Me2)4]-Histone H3 (1-21)-GGK(Biotin)

Sequence One Letter Code: ART-K(Me2)-QTARKSTGGKAPRKQLA-GGK(Biotin)

Sequence Three Letter Code: H-Ala-Arg-Thr-Lys(Me2)-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Gly-Gly-Lys(Biotin)-OH

Molecular Weight: 2751.4

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Lys(Me2)4]-Histone H3 (1–21)-GGK(Biotin) is a synthetic N-terminal histone H3 peptide containing dimethylation at lysine 4, an epigenetic mark associated with active and poised gene promoters. H3K4 dimethylation contributes to transcriptional regulation, chromatin accessibility, and promoter-associated chromatin states. The peptide incorporates a diglycine linker and C-terminal biotinylated lysine, supporting streptavidin-based affinity capture, interaction studies, and enzyme assays. This modified histone peptide is widely used to investigate histone methyltransferase activity, demethylase function, reader protein specificity, chromatin-associated complexes, and methylation-dependent mechanisms of gene regulation.