M871

Product Name:M871

CAS No:908844-75-7

Purity:95%

Molar Mass:2287.64

Chemical Formula:C108H163N27O28

Storage:Store at -20 degrees Celsius

Sequence:WTLNSAGYLLGPEHPPPALALA

Target:GAL2

Application:M871 is a selective antagonist of the galanin receptor 2 (GAL2), which is one of the three known receptors for the neuropeptide galanin. M871 is commonly used in research to study the specific effects of blocking GAL2 signaling pathways. Galanin and its receptors are involved in a variety of physiological processes, including the modulation of pain, mood regulation, feeding behavior, and neuroendocrine functions. By inhibiting GAL2, M871 helps researchers investigate the distinct roles of this receptor, particularly in neuropsychiatric disorders, neuropathic pain, and metabolic conditions, providing insights into the therapeutic potential of targeting GAL2 in these areas.

Current Research:

M871, with the CAS number 908844-75-7, is a synthetic peptide that functions as a selective antagonist for the galanin receptor subtype 2 (GAL2). It exhibits a high binding affinity for GAL2, with a Ki value of 13.1 nM, while showing significantly lower affinity for galanin receptor subtype 1 (GAL1), with a Ki of 420 nM. This selectivity makes M871 a valuable tool for investigating the specific roles of GAL2 in various physiological and pathological processes. Biological Activity M871 has been instrumental in elucidating the functions of GAL2, particularly in the modulation of pain and anxiety: Pain Modulation: Studies have demonstrated that M871 can block the pro-nociceptive effects induced by GAL2 activation. For instance, in rodent models, administration of M871 counteracted the pain-enhancing effects of GAL2 agonists, indicating its potential utility in pain research. Anxiety Regulation: Research involving the infusion of M871 into the dorsal hippocampus of rats has shown that it can mitigate the anxiogenic-like effects induced by galanin, suggesting that GAL2 receptors play a role in anxiety-related behaviors. Research Applications Due to its specificity, M871 serves as a critical tool in: Dissecting the distinct functions of GAL2 receptors in the central and peripheral nervous systems. Investigating the involvement of GAL2 in conditions such as epilepsy, pain, and anxiety disorders. Developing potential therapeutic strategies targeting GAL2-mediated pathways.

Reference:

Sollenberg, U. E., Runesson, J., Sillard, R., & Langel, Ü. (2010). Binding of chimeric peptides M617 and M871 to galanin receptor type 3 reveals characteristics of galanin receptor–ligand interaction. International Journal of Peptide Research and Therapeutics, 16, 17-22.