MGF

Product Name:MGF

Cas No:NA

Purity:95%

Chemical Formula:C124H204N42O41S1

Molar Mass:2971.99

Synonyms:MGF-E, MGF-Ct24E

Storage:-20 degree Celsius

Application:Mechano Growth Factor (MGF) is an alternatively spliced isoform of the insulin-like growth factor-1 (IGF-1) gene, produced in response to mechanical overload or muscle damage. MGF plays a critical role in skeletal muscle regeneration, stimulating satellite cell activation, myoblast proliferation, and tissue repair. Unlike systemic IGF-1, MGF acts locally and rapidly to initiate early phases of muscle adaptation. It is widely used in research focused on muscle wasting, sports injury recovery, aging (sarcopenia), and tissue engineering. MGF is a key tool for investigating muscle repair signaling, regeneration dynamics, and mechano-transduction pathways.

Current Research:

Introduction: What Is Mechano Growth Factor? Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene, produced when tissues are subjected to mechanical stress, such as resistance training or injury. The IGF-1 gene can be alternatively spliced to produce several isoforms, with MGF (also known as IGF-1Ec in humans) emerging as the isoform responsible for initiating muscle repair and local regeneration. MGF was first identified in muscle subjected to stretch or overload and has since become a central focus in regenerative biology, especially for skeletal muscle, tendon, and cardiac tissues. Mechanism of Action: Local Repair and Satellite Cell Recruitment MGF differs from systemic IGF-1 in both structure and function: It contains a unique E-domain peptide sequence at the C-terminus, which enhances its regenerative capabilities. MGF is expressed locally and transiently in muscle fibers following damage or high-intensity contraction. Its primary function is to activate muscle satellite cells (muscle stem cells), leading to increased myoblast proliferation. Unlike mature IGF-1, which promotes differentiation and hypertrophy, MGF’s early role is to initiate the repair cascade, making it essential for muscle regeneration in the initial stages post-injury. Applications in Muscle Growth and Recovery MGF is of significant interest in contexts such as: Muscle injury recovery: Accelerates healing and fiber regeneration Sarcopenia: Counters age-related muscle loss by stimulating regenerative responses Duchenne muscular dystrophy (DMD): May help replenish degenerating muscle fibers Postoperative or disuse atrophy: Promotes regrowth of immobilized or atrophied muscle tissue In animal models, administration of synthetic MGF analogs after muscle trauma enhanced recovery rates, improved muscle fiber density, and increased cross-sectional area compared to untreated controls. Cardiac and Neural Research MGF has also been detected in cardiac tissue post-myocardial infarction. Studies suggest it may: Reduce cardiomyocyte apoptosis Promote myocardial tissue repair Improve cardiac function under ischemic stress Emerging research also shows MGF may exert neuroprotective effects by enhancing neural progenitor proliferation and protecting neurons from oxidative damage. This is currently being explored in models of stroke, spinal cord injury, and neurodegenerative diseases. Aging and Regenerative Capacity MGF expression declines with age, contributing to reduced muscle regenerative capacity in elderly individuals. In preclinical studies: MGF supplementation improved muscle strength and fiber regeneration in aged animals Restored satellite cell responsiveness to injury Reduced biomarkers of muscle inflammation and fibrosis This suggests MGF plays a role in anti-sarcopenia strategies, and may be part of future interventions in aging-related muscle dysfunction. Conclusion: A Key Regulator of Regenerative Response Mechano Growth Factor is a critical player in the early stages of tissue repair, especially in mechanically stressed muscle. Its unique ability to stimulate stem cell activation, promote early-phase regeneration, and support adaptive plasticity distinguishes it from other growth factors. Whether applied in sports injury recovery, muscular disorders, aging, or bioengineering, MGF continues to shape our understanding of tissue adaptation and regenerative medicine.

Reference:

Goldspink, G. (2006). Impairment of IGF-I gene splicing and MGF expression associated with muscle wasting. The international journal of biochemistry & cell biology, 38(3), 481-489.