MSG 606

Product Name:MSG 606

CAS No:1416983-77-1

Purity:95%

Molar Mass:1347.51

Chemical Formula:C62H82N20O13S

Storage:Store at -20 degrees Celsius

Sequence:[{Bua}GH-{d-Phe}-R-{d-Trp}-CDRFG-NH2

Target:MC1R

Application:

MSG 606 is a selective antagonist of the metabotropic glutamate receptor 1 (mGluR1), which plays a critical role in regulating synaptic transmission in the central nervous system. By blocking mGluR1, MSG 606 helps researchers explore its effects on neurological functions, including learning, memory, and pain perception. This compound is of particular interest in studying conditions such as Parkinson’s disease, anxiety disorders, chronic pain, and epilepsy, where dysregulated glutamatergic signaling is a contributing factor. MSG 606 provides valuable insights into the therapeutic potential of targeting mGluR1, offering possibilities for developing treatments for various neurodegenerative and neuropsychiatric disorders.

Current Research:

MSG 606 is a synthetic peptide that acts as a potent and selective antagonist of the melanocortin 1 receptor (MC1R), a G protein-coupled receptor involved in pigmentation and inflammatory responses. With an IC₅₀ of 17 nM for MC1R, MSG 606 demonstrates high specificity and efficacy. Additionally, it exhibits partial agonist activity at the melanocortin 3 receptor (MC3R) and melanocortin 5 receptor (MC5R), with EC₅₀ values of 59 nM and 1,300 nM, respectively. This dual activity highlights its nuanced role in modulating melanocortin signaling pathways.

Mechanism of Action
By binding to MC1R, MSG 606 blocks receptor activation, thereby inhibiting downstream signaling events. This antagonistic effect is critical in regulating processes such as pigmentation and inflammatory responses. The partial agonist effects on MC3R and MC5R suggest potential influences on energy metabolism, immune responses, and other physiological functions regulated by the melanocortin system.

Research Applications
MSG 606 is widely used in studies investigating the role of melanocortin receptors in health and disease:

Pigmentation Research: Its MC1R specificity makes it an essential tool for exploring the molecular mechanisms underlying pigmentation disorders and melanoma development.
Inflammation Studies: MC1R's role in modulating inflammation positions MSG 606 as a valuable reagent in studying inflammatory pathways.
Pain and Gender-Specific Studies: Research indicates that MSG 606 can reverse morphine-induced hyperalgesia in female mice without affecting males, offering potential insights into sex-specific pain mechanisms.
Conclusion
MSG 606 is a highly selective MC1R antagonist with partial agonist properties at MC3R and MC5R. Its versatility and specificity make it an indispensable tool in melanocortin receptor research, contributing to advancements in understanding pigmentation, inflammation, and receptor-targeted therapies.

Reference:

Xu, W., Mo, J., Ocak, U., Travis, Z. D., Enkhjargal, B., Zhang, T., … & Zhang, J. H. (2020). Activation of melanocortin 1 receptor attenuates early brain injury in a rat model of subarachnoid hemorrhage viathe suppression of neuroinflammation through AMPK/TBK1/NF-κB pathway in rats. Neurotherapeutics, 17(1), 294-308.