Myristolated PKCz, Pseudosubstrate (ZIP)

Product Name: Myristolated PKCz, Pseudosubstrate (ZIP)

Sequence One Letter Code: Myr-SIYRRGARRWRKL

Sequence Three Letter Code: Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH

Chemical Formula:C90H154N30O17

Molecular Weight: 1928.5

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: Human, mouse, drosophila, zebrafish, rat

Conjugation: Unconjugated

Code Nacres: NA.26

Application: PKCζ Pseudosubstrate Inhibitor, commonly referred to as ZIP, is a myristoylated peptide corresponding to the pseudosubstrate region of atypical protein kinase C ζ. By mimicking the endogenous pseudosubstrate sequence, ZIP competitively inhibits PKCζ activity and disrupts kinase targeting, localization, and translocation. This peptide has been widely used in neuroscience research to study PKCζ-dependent signaling, synaptic plasticity, and memory-related processes. It is also applied in studies of integrin-dependent adhesion, chemotaxis, immune cell regulation, and PKC-mediated cellular signaling. ZIP is valuable for dissecting atypical PKC pathway function.