NMB-1

Product Name:NMB-1

CAS No:2843557-76-4

Purity:95%

Molar Mass:2466.98

Chemical Formula:C111H164N36O21S4

Storage:Store at -20 degrees Celsius

Sequence:FNWRCCLIPCRRNHKKFFC-NH2

Target:sustained mechanically activated currents in sensory neurons

Application:NMB-1 is a selective inhibitor of acid-sensing ion channels (ASICs), specifically targeting the ASIC1a subtype. ASICs are proton-gated ion channels that play critical roles in pain perception, neuroinflammation, and neuronal damage under acidic conditions, such as during ischemia or injury. By inhibiting ASIC1a, NMB-1 helps reduce neuronal excitability and protect against acid-induced neuronal damage. This compound is widely used in research to study ASIC-related physiological processes and pathological conditions, including chronic pain, stroke, and neurodegenerative diseases. NMB-1 is a valuable tool for exploring new therapeutic approaches targeting ASIC1a for neuroprotection and pain relief.

Current Research:

NMB-1 is a synthetic conopeptide analogue that selectively inhibits sustained mechanically activated currents in sensory neurons, with an IC50 of approximately 1 μM. This inhibition effectively attenuates mechanical pain, making NMB-1 a valuable tool for researching conditions related to hearing and pressure-evoked pain. Mechanism of Action NMB-1 targets and inhibits sustained mechanically activated ion channels in sensory neurons. By blocking these channels, it reduces the neuronal response to mechanical stimuli, thereby alleviating mechanical pain. This selective action makes it a promising candidate for understanding the pathways of mechanical pain and sensory modulation. Research Applications NMB-1 has broad utility in neurophysiological research due to its specific action on mechanically activated currents: Pain Studies: It provides insights into the mechanisms underlying mechanical pain and offers a model for developing pain-relief therapeutics. Hearing Research: By modulating sensory neurons involved in auditory pathways, it aids in understanding the processes of mechanotransduction in hearing. Pressure-Induced Disorders: NMB-1 is used to explore therapeutic strategies for conditions where mechanical pressure leads to neuronal dysfunction. Handling and Storage NMB-1 is typically supplied as a lyophilized powder. For optimal stability, it should be stored at -20 degrees Celsius, protected from light and moisture. Upon reconstitution, aliquots should be prepared to prevent repeated freeze-thaw cycles, which can degrade the peptide. Conclusion NMB-1 is a potent inhibitor of mechanically activated currents in sensory neurons, offering significant insights into pain modulation and sensory research. Its applications extend from understanding mechanosensory pathways to the development of novel therapeutics targeting mechanical pain and hearing disorders.

Reference:

Drew, L. J., Rugiero, F., Cesare, P., Gale, J. E., Abrahamsen, B., Bowden, S., … & Wood, J. N. (2007). High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PloS one, 2(6), e515.