[(pF)Phe4]Nociceptin(1-13)NH2

Product Name:[(pF)Phe4]Nociceptin(1-13)NH2

CAS No:380620-88-2

Purity:95%

Molar Mass:1471.5

Chemical Formula:C61H95F5N22O15

Storage:Store at -20 degrees Celsius

Sequence:FGGXTGARKSARK

Target:NOP

Application:

[(pF)Phe?]Nociceptin(1-13)NH2 is a modified fragment of nociceptin/orphanin FQ, enhanced by incorporating a para-fluorophenylalanine (pF) residue at position four. This synthetic peptide targets the nociceptin receptor (NOP) with improved stability and receptor binding affinity. It is primarily used in research to explore the nociceptin/NOP receptor system, which plays a significant role in pain modulation, anxiety, and stress responses. By studying the interactions of [(pF)Phe?]Nociceptin(1-13)NH2 with NOP, researchers can gain insights into the receptor's structure-activity relationships, contributing to the development of potential therapeutic agents for managing pain and neuropsychiatric conditions.

Current Research:

[(pF)Phe4]Nociceptin(1-13)NH2 is a synthetic peptide analog of nociceptin/orphanin FQ, a neuropeptide that acts as an endogenous ligand for the nociceptin opioid receptor (NOP, also known as ORL-1). This modified peptide incorporates a para-fluorinated phenylalanine residue at position 4, enhancing its pharmacological properties and stability. The compound retains high specificity and affinity for the NOP receptor, making it a valuable tool for probing nociceptin receptor functions and therapeutic potential.
Recent research emphasizes [(pF)Phe4]Nociceptin(1-13)NH2's role in modulating pain pathways. Unlike classical opioid peptides, nociceptin and its analogs can exhibit anti-opioid or pronociceptive effects depending on the context, offering a unique approach to pain management without the addiction risks associated with traditional opioids. Studies on [(pF)Phe4]Nociceptin(1-13)NH2 have demonstrated its potential in altering nociceptive signaling and managing conditions such as neuropathic pain and hyperalgesia.
Additionally, [(pF)Phe4]Nociceptin(1-13)NH2 is gaining attention in neuropsychiatric research. The NOP receptor system is implicated in stress, anxiety, depression, and substance abuse disorders. This peptide analog serves as a potent ligand to explore these pathways, aiding in the development of NOP-targeted therapies.
Preclinical models have also explored its cardiovascular effects, as the NOP receptor influences blood pressure regulation. The modified structure of [(pF)Phe4]Nociceptin(1-13)NH2 improves its resistance to enzymatic degradation, prolonging its activity and enabling more consistent experimental outcomes.
In summary, [(pF)Phe4]Nociceptin(1-13)NH2 is a powerful research tool for studying NOP receptor pharmacology. Its potential to modulate pain, mood disorders, and physiological processes continues to inspire investigations into novel therapeutic avenues.

Reference:

Guerrini, R., Cal??, G., Bigoni, R., Rizzi, D., Rizzi, A., Zucchini, M., ... & Regoli, D. (2001). Structure? activity studies of the Phe4 residue of nociceptin (1? 13)-NH2: Identification of highly potent agonists of the nociceptin/orphanin FQ receptor. Journal of medicinal chemistry, 44(23), 3956-3964.