Thrombin Receptor Activator for Peptide 6 (TRAP-6)

Product Name: Thrombin Receptor Activator for Peptide 6 (TRAP-6)

Sequence One Letter Code: SFLLRN

Sequence Three Letter Code: H-Ser-Phe-Leu-Leu-Arg-Asn-OH

Cas No: 141136-83-6

Chemical Formula:C34H56N10O9

Molecular Weight: 748.9 Purity: ≥ 95% Form: Lyophilized

Storage Conditions: - 20 °C

Research Area:

SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)N

IUPAC: (2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoic acid

INCHIKEY: HAGOWCONESKMDW-FRSCJGFNSA-N

INCHI:

InChI=1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

Source / Species: human

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Thrombin Receptor Activator Peptide-6 (TRAP-6) is a short peptide corresponding to residues 42–47 of protease-activated receptor-1. It acts as a tethered ligand mimic and directly activates PAR-1 without requiring thrombin-mediated proteolytic cleavage. TRAP-6 induces platelet activation, intracellular signaling, and thromboxane production, making it an important tool for platelet function studies. It has also been reported to activate PAR-2 under certain experimental conditions. TRAP-6 is widely used in research on protease-activated receptor signaling, platelet aggregation, vascular biology, inflammatory responses, coagulation pathways, and thrombin-related cellular activation mechanisms.