37, 40Gap 26, Connexin Mimetic

Product Name: 37, 40Gap 26, Connexin Mimetic

Sequence One Letter Code: VCYDQAFPISHIR

Sequence Three Letter Code: H-Val-Cys-Tyr-Asp-Gln-Ala-Phe-Pro-Ile-Ser-His-Ile-Arg-OH

Chemical Formula:C70H105N19O19S1

Molecular Weight: 1548.9

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: Human, mouse, rat, bovine

Conjugation: Unconjugated

Code Nacres: NA.26

Application: 37,40Gap 26 is a connexin mimetic peptide corresponding to the GAP26 domain of the extracellular loop shared by vascular connexins Cx37 and Cx40. These connexins form gap junction plaques that are abundantly expressed in endothelial cells and support intercellular communication. This peptide is used to investigate the role of endothelial gap junctions in the spread of hyperpolarization responses within blood vessel walls. By inhibiting gap junction communication, 37,40Gap 26 provides a valuable tool for studying connexin-mediated signaling, vascular tone regulation, endothelial physiology, cardiovascular function, and intercellular electrical coupling.