40Gap 27, Connexin Mimetic

Product Name: 40Gap 27, Connexin Mimetic

Sequence One Letter Code: SRPTEKNVFIV

Sequence Three Letter Code: H-Ser-Arg-Pro-Thr-Glu-Lys-Asn-Val-Phe-Ile-Val-OH

Chemical Formula:C58H96N16O17

Molecular Weight: 1289.6

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: Human, mouse, rat, bovine

Conjugation: Unconjugated

Code Nacres: NA.26

Application: 40Gap 27 is a connexin mimetic peptide corresponding to the GAP27 domain of the second extracellular loop of connexin 40, a dominant vascular connexin. It is used to investigate gap junction-mediated intercellular communication, especially under oxidative stress conditions. In vascular studies, 40Gap 27 has been shown to attenuate endothelium-dependent subintimal smooth muscle hyperpolarization. This peptide is valuable for research on endothelial function, vascular signaling, connexin biology, redox biology, and mechanisms by which oxidative stress disrupts gap junction communication in cardiovascular and endothelial physiology models.