[Arg(Me2s)3]-Histone H4 (1-21)-GGK(Biotin)

Product Name: [Arg(Me2s)3]-Histone H4 (1-21)-GGK(Biotin)

Sequence One Letter Code: Ac-SG-R(me2s)-GKGGKGLGKGGAKRHRKV-GGK(biotin)

Sequence Three Letter Code: Ac-Ser-Gly-Arg(me2s)-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val--Gly-Gly-Lys(biotin)

Molecular Weight: 2630.3

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: [Arg(Me2s)3]-Histone H4 (1–21)-GGK(Biotin) is a synthetic N-terminal histone H4 peptide symmetrically dimethylated at arginine 3 and biotinylated through a C-terminal GG linker and lysine. Symmetric H4R3 dimethylation is associated with transcriptional repression, chromatin compaction, and modification-dependent epigenetic regulation. The biotin tag enables affinity capture, immobilization, pull-down assays, and protein-binding studies using streptavidin-based systems. This modified histone peptide is widely used to study arginine methylation-dependent chromatin regulation, histone reader proteins, epigenetic enzyme specificity, chromatin-associated protein interactions, and transcriptional repression mechanisms.