Biotin-ACTH (1-39), Human

Product Name:Biotin-ACTH (1-39), Human

Form:TFA salt

Purity:95%

Storage:2-8 degree Celsius

Molar Mass:3659.2

Chemical Formula:C167H257N47O46

Sequence:Biotin-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

Application:Biotin-ACTH (1-39), Human is a biotinylated form of the full-length adrenocorticotropic hormone (ACTH), a key regulator of adrenal steroidogenesis via melanocortin 2 receptor (MC2R) activation. The addition of biotin enables enhanced detection, tracking, and affinity-based studies in biochemical and cell-based assays. This peptide plays a crucial role in research on HPA axis function, adrenal insufficiency, and stress-related disorders. Biotin-ACTH (1-39) is widely used in receptor-ligand interaction studies, immunoassays, and neuroendocrinology research, helping to elucidate melanocortin signaling pathways in endocrinology, neurobiology, and metabolic regulation.

Current Research:

Introduction
Adrenocorticotropic hormone (ACTH) is a crucial peptide hormone involved in adrenal function, stress response, and neuroendocrine signaling. The biotinylation of ACTH (1-39) enhances its research applications by facilitating detection, tracking, and affinity-based interactions. Biotin-ACTH (1-39), human, is widely used in studies on melanocortin receptor binding, adrenal steroidogenesis, and peptide-receptor interactions. This modified ACTH is especially valuable in biochemical assays, receptor-ligand interaction studies, and immunodetection methodologies.

Endocrine and Adrenal Function Research
Biotin-ACTH (1-39) retains the full biological activity of native ACTH, allowing researchers to investigate glucocorticoid regulation via the melanocortin 2 receptor (MC2R). This makes it a key tool for studying disorders such as adrenal insufficiency, Cushing’s syndrome, and Addison’s disease.

Using biotinylated ACTH in binding assays and receptor-ligand studies provides insights into MC2R activation, downstream signaling cascades, and adrenal steroid production. These studies contribute to the development of novel therapies for adrenal dysfunction and synthetic ACTH analogs for clinical applications.

Neuroendocrine and Stress-Related Research
ACTH plays a pivotal role in the hypothalamic-pituitary-adrenal (HPA) axis, a key regulatory system for stress adaptation and homeostasis. Biotin-ACTH (1-39) is utilized in studies examining stress-induced hormonal fluctuations, neuropeptide signaling, and HPA axis dysfunctions. Research in this area contributes to understanding chronic stress disorders, depression, and post-traumatic stress disorder (PTSD).

Additionally, ACTH is linked to neuromodulation and cognitive function through interactions with melanocortin receptors in the brain. By using biotinylated ACTH in neuroendocrine receptor studies, researchers can explore its role in neuroinflammation, learning, and neuroprotection, with potential implications in neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Immunological and Inflammatory Research
ACTH has well-documented anti-inflammatory and immunomodulatory effects, interacting with melanocortin receptors on immune cells. Biotin-ACTH (1-39) is applied in cytokine regulation studies, immune response profiling, and inflammatory pathway analysis. Its use in biotin-based detection assays allows for precise tracking of melanocortin-mediated immune modulation, which is relevant for research into autoimmune diseases, multiple sclerosis, and rheumatoid arthritis.

Biotinylation and Research Applications
The addition of biotin enhances ACTH’s detection and tracking in various experimental settings, including:

Receptor-ligand interaction studies: Enables precise mapping of melanocortin receptor binding and ACTH-mediated signaling.
Affinity-based detection assays: Facilitates enzyme-linked immunosorbent assays (ELISA), Western blotting, and pull-down assays.
Cell-based imaging and tracking: Allows researchers to visualize ACTH dynamics in live-cell imaging studies.
These applications significantly enhance the accuracy and sensitivity of ACTH-related research, making Biotin-ACTH (1-39), human, a valuable tool in endocrinology, immunology, and neuroscience.

Conclusion
Biotin-ACTH (1-39), human, is a modified peptide designed for enhanced detection and research applications in endocrinology, neurobiology, and immunology. It enables high-sensitivity tracking of ACTH interactions, making it essential for melanocortin receptor studies, adrenal function research, and HPA axis analysis. Ongoing studies continue to expand its use in stress physiology, immune modulation, and neuroendocrine signaling, paving the way for novel therapeutic insights into adrenal, neurological, and inflammatory disorders.