Autocamtide-2-Related Inhibitory Peptide (AIP); CaMKII Inhibitor, myristoylated

Product Name: Autocamtide-2-Related Inhibitory Peptide (AIP); CaMKII Inhibitor, myristoylated

Sequence One Letter Code: Myr-KKALRRQEAVDAL

Sequence Three Letter Code: Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH

Chemical Formula:C78H142N22O20

Molecular Weight: 1708.2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Conjugation: Unconjugated

 Code Nacres: NA.26

Application: Myristoylated Autocamtide-2-Related Inhibitory Peptide is a potent and highly specific inhibitor of calmodulin-dependent protein kinase II. Derived from the CaMKII substrate autocamtide-2, this peptide contains an alanine substitution at the Thr-9 phosphorylation site, producing substrate-competitive inhibitory activity. Myristoylation enhances cellular uptake and membrane association, supporting use in cell-based signaling studies. This peptide is widely used to selectively inhibit CaMKII activity and investigate calcium-dependent signal transduction. It is valuable in neuroscience, cardiac signaling, synaptic plasticity, kinase regulation, cellular physiology, and studies of CaMKII-mediated pathways in health and disease.