Bax inhibitor peptide, negative control

Product Name:Bax inhibitor peptide, negative control

Synonyms:(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-3-methylpentanoyl]amino]hexanoic acid

CAS No:1315378-74-5

Purity:95%

Molar Mass:600.8

Chemical Formula:C28H52N6O6S

Storage:Store at -20 degrees Celsius

Sequence:IPMIK

Application:

Bax Inhibitor Peptide, Negative Control is a non-functional peptide designed to serve as a negative control in experiments involving Bax-mediated apoptosis pathways. This peptide is structurally similar to the active Bax inhibitor peptide but lacks the ability to interfere with Bax activity, making it ideal for validating the specificity and efficacy of Bax inhibition in experimental setups. Bax Inhibitor Peptide, Negative Control is essential for ensuring the accuracy and reliability of apoptosis studies, providing a baseline to compare the effects of Bax inhibition. Its high purity and stability ensure consistent performance in research applications.

Current Research:

Bax inhibitor peptide, negative control (CAS: 1315378-74-5), is a synthetic pentapeptide with the sequence H-Ile-Pro-Met-Ile-Lys-OH. It serves as a negative control for Bax inhibitor peptides, such as V5 and P5, which are known to inhibit Bax translocation to mitochondria and Bax-mediated apoptosis. This control peptide is designed to match the structural properties of active Bax inhibitors without exerting inhibitory effects on Bax function, thereby providing a baseline for experimental comparisons.
In apoptosis research, employing a negative control peptide like this is crucial for validating the specificity and efficacy of Bax inhibitor peptides. By comparing the effects of the active inhibitor with those of the negative control, researchers can discern whether observed cellular responses are due to specific inhibition of Bax or are nonspecific effects. This approach enhances the reliability of data concerning Bax's role in apoptotic pathways.
Despite its utility in research, the commercial availability of Bax inhibitor peptide, negative control, has become limited. Some suppliers have discontinued its sale for unspecified reasons. Researchers interested in utilizing this peptide may need to explore alternative sources or consider custom synthesis to obtain it for their studies.
In summary, Bax inhibitor peptide, negative control, is an essential tool in apoptosis research, enabling the validation of experimental outcomes related to Bax inhibition. Its use ensures that the effects attributed to Bax inhibitors are specific and not due to off-target interactions, thereby contributing to the accuracy and integrity of apoptosis studies.

Reference:

Wang, X., Han, W., Du, X., Zhu, C., Carlsson, Y., Mallard, C., ... & Hagberg, H. (2010). Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury. Stroke, 41(9), 2050-2055.