Camstatin

Product Name:Camstatin

Synonyms:AKOS024458712

CAS No:1002295-95-5

Purity:95%

Molar Mass:2760.2

Chemical Formula:C122H203N39O34

Storage:Store at -20 degrees Celsius

Sequence:APETERAAVAIQAQFRKFQKKKAGS

Application:

Camstatin is a synthetic peptide designed for research and potential therapeutic applications, particularly in the field of cancer biology. It is derived from or modeled after naturally occurring peptides known for their ability to inhibit specific proteases, which play a crucial role in tumor growth and metastasis. By targeting these proteases, Camstatin can potentially hinder the progression of certain cancers, making it a promising candidate for the development of anti-cancer therapies. Additionally, Camstatin is valuable in research focused on understanding the molecular mechanisms of cancer invasion and metastasis, as well as in the development of new strategies for cancer treatment.

Current Research:

Camstatin is a synthetic peptide derived from the calmodulin-binding IQ motif of PEP-19, a neuronal calpacitin protein. Comprising 25 amino acids, Camstatin binds to calmodulin (CaM) and modulates the activity of CaM-dependent enzymes, notably neuronal nitric oxide synthase (nNOS) and CaM kinase II.
By interacting with calmodulin, Camstatin inhibits the activation of these enzymes, thereby influencing various calcium-mediated cellular processes. This inhibition has been instrumental in research exploring the regulation of nitric oxide production and calcium signaling pathways. Additionally, Camstatin has been shown to block vanilloid-induced calcium uptake in TRPV1-expressing cells, suggesting its potential role in modulating pain perception and inflammatory responses.
The peptide's ability to selectively bind to calmodulin without activating downstream signaling pathways makes it a valuable tool in neurobiological studies. It aids in dissecting the complex interactions between calmodulin and its target proteins, offering insights into the molecular mechanisms underlying neuronal function and dysfunction.
In summary, Camstatin serves as a potent modulator of calmodulin-dependent activities, providing a framework for understanding calcium-dependent signaling in neuronal contexts and offering potential therapeutic avenues for conditions associated with dysregulated calcium signaling.

Reference:

Israel, O. (2010). Investigation of the effect mutations of CaM have upon in vitro and ex vivo function (Master's thesis, University of Waterloo).