C-Peptide-d3 (Proinsulin) TFA Salt

Product Name:C-Peptide-d3 (Proinsulin) TFA Salt

Synonyms:C Peptide-d3, C-Peptide Insulin C-peptide-d3, NMIJ-CRM 6901a-d3, Peptide C-d3, Proinsulin Connecting Peptide-d3

Purity:95%

Molar Mass:2754.84114

Chemical Formula:C112H176D3N35O46 • x(C2HF3O2)

Storage:Store at -20 degrees Celsius

Application:

C-Peptide-d3 (Proinsulin) TFA Salt is a deuterium-labeled version of the C-peptide, which is part of the proinsulin molecule and is cleaved during the process of insulin production. This labeled peptide is used in research to study insulin secretion, glucose metabolism, and the overall function of the pancreas. The deuterium labeling (d3) allows for precise tracking in metabolic and pharmacokinetic studies, particularly in mass spectrometry applications. The trifluoroacetate (TFA) salt form enhances its stability and solubility, making it useful in experimental setups. C-Peptide-d3 is important in understanding diseases like diabetes and assessing pancreatic function.

Current Research:

C-Peptide-d₃ (Proinsulin) TFA Salt is a deuterium-labeled analog of the endogenous C-peptide, which connects the A and B chains of insulin in its precursor form, proinsulin. The incorporation of three deuterium atoms allows for precise tracking in metabolic and pharmacokinetic studies, particularly when employing mass spectrometry techniques. The trifluoroacetate (TFA) salt form enhances the compound's stability and solubility, facilitating its use in various experimental setups.

Applications in Research

C-Peptide-d₃ serves as an internal standard in quantitative analyses of proinsulin, C-peptide, and insulin within biological samples. Its stable isotope labeling enables accurate measurement of these peptides, which is crucial for research into insulin production, secretion, and related metabolic disorders.

Clinical Relevance

Accurate quantification of C-peptide levels is essential for distinguishing between type 1 and type 2 diabetes, as it reflects endogenous insulin production. Utilizing C-Peptide-d₃ as a standard enhances the precision of these measurements, thereby improving diagnostic accuracy.

Handling and Storage

As a hygroscopic compound, C-Peptide-d₃ (Proinsulin) TFA Salt should be stored at -20°C under an inert atmosphere to maintain its integrity. Proper storage conditions are vital to preserve its stability for research applications.

Conclusion

C-Peptide-d₃ (Proinsulin) TFA Salt is a valuable tool in diabetes research and metabolic studies, offering enhanced accuracy in the quantification of insulin-related peptides. Its stable isotope labeling and improved solubility make it indispensable for advancing our understanding of insulin physiology and associated disorders.