Caspase 8 Substrate 1f, fluorogenic

Product Name: Caspase 8 Substrate 1f, fluorogenic

Sequence One Letter Code: Ac-IETD-AFC

Sequence Three Letter Code: Ac - Ile-Glu-Thr-Asp - AFC

Chemical Formula:C31H38F3N5O12

Molecular Weight: 729.6

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C Protected from light

Conjugation: Conjugated

Conjugation Type: Fluorescent dyes

Code Nacres: NA.26

Application: Caspase-8 Fluorogenic Substrate is designed for sensitive detection of caspase-8 activity, a key initiator enzyme in extrinsic apoptosis signaling pathways. Upon enzymatic cleavage, the AFC fluorophore is released, producing strong fluorescence measurable at excitation 370–390 nm and emission 500–510 nm. Caspase-8 substrates are widely used to monitor apoptosis activation, death receptor signaling, and immune-related programmed cell death pathways. This reagent supports quantitative analysis in biochemical assays and cellular apoptosis models. Caspase-8 Fluorogenic Substrate is valuable for apoptosis research, immune signaling studies, oncology research, and drug discovery screening.