Product Name:α-CGRP (human)
CAS No:90954-53-3
Purity:95%
Molar Mass:3789.33
Chemical Formula:C163H267N51O49S2
Storage:Store at -20 degrees Celsius
Sequence:ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF
Target:CGRP
Application:
α-CGRP (human), also known as alpha-Calcitonin Gene-Related Peptide, is a neuropeptide involved in various physiological processes, including vasodilation, pain transmission, and inflammatory responses. It is predominantly found in the central and peripheral nervous systems and plays a crucial role in regulating cardiovascular functions and nociception. In pharmaceutical research, α-CGRP is extensively studied for its involvement in migraine pathophysiology, as it is a potent vasodilator linked to migraine attacks. This peptide is also relevant in exploring therapeutic interventions targeting CGRP receptors to alleviate migraines and other neurovascular conditions.
Current Research:
α-Calcitonin Gene-Related Peptide (α-CGRP) is a 37-amino acid neuropeptide widely distributed in both the central and peripheral nervous systems. It is derived from the alternative splicing of the calcitonin gene and functions as a potent vasodilator, playing a crucial role in various physiological processes.
Structure and Distribution
α-CGRP is produced through tissue-specific alternative splicing of the calcitonin/CGRP gene. In neuronal tissues, this splicing favors the production of α-CGRP, whereas in the thyroid gland, it leads to the production of calcitonin. This peptide is abundantly present in sensory nerves, particularly within the dorsal root and trigeminal ganglia, and is also found in the gastrointestinal tract and cardiovascular system.
Physiological Functions
Vasodilation: α-CGRP is recognized as one of the most potent endogenous vasodilators. It induces relaxation of vascular smooth muscle cells, leading to the dilation of blood vessels and a subsequent decrease in blood pressure. This effect is mediated through the activation of adenylate cyclase and an increase in cyclic AMP levels within target cells.
Pain Transmission: In the nervous system, α-CGRP is involved in the transmission of pain signals. It is released from sensory neurons in response to noxious stimuli and contributes to neurogenic inflammation by promoting vasodilation and the release of pro-inflammatory mediators.
Migraine Pathophysiology: Elevated levels of α-CGRP have been implicated in the pathogenesis of migraines. During migraine attacks, increased release of α-CGRP leads to vasodilation of cerebral blood vessels and transmission of pain, making it a target for therapeutic intervention.
Clinical Implications
The significant role of α-CGRP in vasodilation and pain transmission has made it a focal point in clinical research:
Migraine Treatment: Monoclonal antibodies targeting α-CGRP or its receptor have been developed as preventive treatments for migraines. For instance, fremanezumab is a monoclonal antibody that binds to α-CGRP, inhibiting its activity and thereby reducing the frequency of migraine attacks.
Cardiovascular Research: Due to its vasodilatory properties, α-CGRP is being studied for its potential therapeutic applications in cardiovascular diseases, such as hypertension and heart failure.
Research Applications
Synthetic α-CGRP (human) is utilized in scientific research to study its physiological and pathological roles. It serves as a tool to investigate the mechanisms underlying its vasodilatory effects, involvement in pain pathways, and potential as a therapeutic target in various diseases.
Conclusion
α-CGRP is a multifunctional neuropeptide with significant roles in vasodilation, pain transmission, and the pathophysiology of migraines. Ongoing research continues to explore its potential as a therapeutic target in treating migraines and cardiovascular conditions.
Reference:
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