Cyclo (RGDfC), avb3 Integrin Binding Cyclic RGD Peptide

Product Name: Cyclo (RGDfC), avb3 Integrin Binding Cyclic RGD Peptide

Sequence One Letter Code: Cyclo(-RGDfC)

Sequence Three Letter Code: Cyclo(-Arg-Gly-Asp-D-Phe-Cys)

Cas No: 862772-11-0

Chemical Formula:C24H34N8O7S

Molecular Weight: 578.7

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

SMILES: C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CS)CC2=CC=CC=C2)CC(=O)O

IUPAC: 2-[5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-(sulfanylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid

INCHIKEY: WNYJVAMZRBTOPE-UHFFFAOYSA-N

INCHI:

InChI=1S/C24H34N8O7S/c25-24(26)27-8-4-7-14-20(36)28-11-18(33)29-16(10-19(34)35)22(38)31-15(9-13-5-2-1-3-6-13)21(37)32-17(12-40)23(39)30-14/h1-3,5-6,14-17,40H,4,7-12H2,(H,28,36)(H,29,33)(H,30,39)(H,31,38)(H,32,37)(H,34,35)(H4,25,26,27)

Source / Species: synthetic

Conjugation: Unconjugated

Code Nacres: NA.26

Application: Cyclo(RGDfC) is a cyclic RGD peptide with high affinity for the αvβ3 integrin, a receptor involved in cell adhesion, angiogenesis, and tumor progression. The cyclic structure enhances receptor specificity and peptide stability compared with linear RGD sequences. Because αvβ3 integrin is highly expressed on activated endothelial cells and many tumor cells, Cyclo(RGDfC) is widely used as a probe for integrin-mediated signaling and targeting studies. This peptide supports research on cell–matrix interactions, angiogenesis, tumor vascular biology, integrin-targeted imaging, drug delivery, and therapeutic strategies focused on tumor-associated integrins.