[D-Trp7,9,10]-Substance P

Product Name:[D-Trp7,9,10]-Substance P

Synonyms:[D-Trp7,9,10]-Substance P

CAS No:89430-38-6

Purity:95%

Molar Mass:1588.9

Chemical Formula:C79H105N21O13S

Storage:Store at -20 degrees Celsius

Sequence:RPKPQQWFWWM

Target:neurokinin NK1 receptor

Application:

[D-Trp7,9,10]-Substance P is a synthetic analog of the neuropeptide Substance P, designed with D-tryptophan substitutions at positions 7, 9, and 10. This modification enhances the stability and resistance to enzymatic degradation of the peptide, making it a valuable tool for research into pain modulation, neuroinflammation, and neurogenic inflammation. [D-Trp7,9,10]-Substance P retains the ability to bind to neurokinin-1 (NK1) receptors, allowing researchers to investigate the physiological and pathological roles of Substance P in various conditions. Its high purity and enhanced stability ensure reliable performance in experimental studies focused on nervous system functions.

Current Research:

[D-Trp7,9,10]-Substance P is a synthetic analog of the neuropeptide Substance P, engineered to act as an antagonist at neurokinin-1 (NK1) receptors. By substituting the seventh, ninth, and tenth amino acids with D-tryptophan residues, this analog effectively inhibits NK1 receptor-mediated signaling pathways. Mechanism of Action The incorporation of D-tryptophan at specific positions alters the peptide's conformation, enhancing its binding affinity for NK1 receptors while preventing receptor activation. This competitive antagonism blocks the effects of endogenous Substance P, which is involved in processes such as pain transmission, inflammation, and stress responses. Pharmacological Applications In experimental models, [D-Trp^7,9,10]-Substance P has been utilized to investigate the role of NK1 receptors in various physiological and pathological conditions. For instance, studies have shown that this antagonist can modulate cardiovascular responses and influence arrhythmogenic activity in isolated rat hearts. Specifically, it has been observed to affect norepinephrine-induced ventricular arrhythmias, suggesting its potential in cardiac research. Research Implications The use of [D-Trp^7,9,10]-Substance P provides valuable insights into the functions of NK1 receptors and the physiological roles of Substance P. By selectively inhibiting these receptors, researchers can delineate the contributions of Substance P to various biological processes, including pain perception, cardiovascular regulation, and immune responses. Conclusion As a potent NK1 receptor antagonist, [D-Trp^7,9,10]-Substance P serves as a crucial tool in neuropharmacological research, aiding in the exploration of therapeutic targets for conditions associated with dysregulated Substance P signaling.

Reference:

Lee, K. W., Kim, K., Kim, H. C., Lee, S. Y., & Jang, C. G. (2018). The role of striatal Gαq/11 protein in methamphetamine-induced behavioral sensitization in mice. Behavioural Brain Research, 346, 66-72.