[Des-octanoyl]-Ghrelin (human)

Product Name:[Des-octanoyl]-Ghrelin (human)

CAS No:313951-59-6

Purity:95%

Molar Mass:3244.51

Chemical Formula:C141H235N47O41

Storage:Store at -20 degrees Celsius

Sequence:GSSFLSPEHQRVQQRKESKKPPAKLQPR

Application:[Des-octanoyl]-Ghrelin (human) is a modified form of the peptide hormone ghrelin, which lacks the octanoyl group at the serine 3 position. Ghrelin, often referred to as the "hunger hormone," is primarily involved in regulating appetite, energy balance, and growth hormone release. The octanoyl modification is crucial for ghrelin's binding to its receptor, the growth hormone secretagogue receptor (GHS-R). However, [Des-octanoyl]-Ghrelin, lacking this modification, does not activate GHS-R and is often used in research to study the effects of ghrelin independent of its receptor-mediated actions. This peptide is valuable for investigating alternative pathways and functions of ghrelin in metabolic regulation, cardiovascular health, and other physiological processes.

Current Research:

[Des-octanoyl]-Ghrelin, also known as des-acyl ghrelin, is the non-acylated form of the peptide hormone ghrelin. This form lacks the octanoyl group at serine-3, which is essential for binding to the growth hormone secretagogue receptor (GHS-R1a) and stimulating growth hormone release. Consequently, [Des-octanoyl]-Ghrelin does not activate GHS-R1a or induce growth hormone secretion, yet it exerts distinct biological effects independent of this receptor.
Biological Functions
Cardiovascular Regulation: [Des-octanoyl]-Ghrelin has cardioprotective properties and influences cardiac muscle function by exerting negative inotropic effects.
Antiproliferative Activity: It inhibits cell proliferation in certain cancer cell lines, including those of breast and prostate origins, suggesting potential roles in cancer biology.
Metabolic Effects: The peptide promotes adipogenesis and regulates glucose metabolism, including reducing glucose output by hepatocytes, contributing to energy balance and metabolic homeostasis.
Physiological Relevance
Circulating levels of [Des-octanoyl]-Ghrelin are significantly higher than its acylated counterpart, emphasizing its physiological importance. These levels suggest that the peptide has roles beyond those mediated by the classical ghrelin receptor, potentially involving other receptors or novel signaling mechanisms.
Research Applications
[Des-octanoyl]-Ghrelin is a valuable research tool in the study of:
Cardiovascular health and the development of cardioprotective therapies.
Cancer biology, focusing on its antiproliferative effects.
Metabolic disorders, including diabetes and obesity, by exploring its influence on energy balance and glucose metabolism.
Non-classical receptor pathways and novel biological interactions.
Conclusion
[Des-octanoyl]-Ghrelin represents a crucial area of study due to its unique biological activities and potential therapeutic applications. Its non-classical effects highlight the complexity of ghrelin biology and its broader implications in health and disease.

Reference:

Gauna, C., Delhanty, P. J., Hofland, L. J., Janssen, J. A., Broglio, F., Ross, R. J., ... & van der Lely, A. J. (2005). Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. The Journal of Clinical Endocrinology & Metabolism, 90(2), 1055-1060.