Desmopressin acetate trihydrate

Product Name:Desmopressin acetate trihydrate

Synonyms:Minirin

CAS No:62357-86-2

Purity:95%

Molar Mass:1183.3

Chemical Formula:C48H74N14O17S2

Storage:Store at -20 degrees Celsius

Sequence:CYFQNCPRG

Application:

Desmopressin acetate trihydrate is a synthetic analog of the natural hormone vasopressin, specifically designed to mimic its antidiuretic effects. This peptide is commonly used in the treatment of conditions like diabetes insipidus, nocturnal enuresis (bedwetting), and certain cases of hemophilia and von Willebrand disease. Desmopressin works by increasing water reabsorption in the kidneys, thereby reducing urine production. It also stimulates the release of clotting factors, which is beneficial in managing bleeding disorders. The trihydrate form ensures the compound's stability and solubility, making it suitable for various formulations, including tablets, nasal sprays, and injectables. Desmopressin acetate trihydrate is a vital therapeutic agent for managing fluid balance and bleeding disorders effectively.

Current Research:

Desmopressin Acetate Trihydrate is a synthetic analog of the natural antidiuretic hormone arginine vasopressin. It exhibits selective agonist activity at V2 receptors in the renal collecting ducts, enhancing water reabsorption and reducing urine output. This mechanism underpins its primary clinical application in the treatment of conditions such as central diabetes insipidus, nocturnal enuresis, and certain cases of von Willebrand disease and mild hemophilia A. Structurally, desmopressin differs from vasopressin by the substitution of D-arginine for L-arginine at position 8 and the removal of the N-terminal cysteine's disulfide bridge. These modifications increase its stability, prolong its half-life, and reduce vasoconstrictive activity, conferring a more targeted therapeutic profile. In research contexts, desmopressin acetate trihydrate is used to study renal physiology, water-electrolyte balance, and the pharmacodynamics of vasopressin analogs. Its role in modulating V2 receptor activity also makes it a valuable tool for exploring mechanisms of action for drugs targeting aquaporin-mediated water transport. This compound is supplied as a trihydrate form, ensuring stability and ease of handling. For experimental purposes, it is typically reconstituted in water or saline under sterile conditions. Proper storage, usually at -20 degrees Celsius, is essential to maintain its biological activity. Desmopressin acetate trihydrate continues to play a critical role both in therapeutic applications and in advancing our understanding of antidiuretic hormone pathways, serving as a model compound for drug development and physiological studies.

Reference:

Hara, Y., Masuda, H., Taoda, T., Hasegawa, D., Fujita, Y., Nezu, Y., & Tagawa, M. (2003). Prophylactic efficacy of desmopressin acetate for diabetes insipidus after hypophysectomy in the dog. Journal of veterinary medical science, 65(1), 17-22.