Dynamin inhibitory peptide, myristoylated

Product Name:Dynamin inhibitory peptide, myristoylated

Synonyms:Dynamin inhibitory peptide,myristoylated

CAS No:251634-22-7

Purity:95%

Molar Mass:1330.6

Chemical Formula:C61H107N19O14

Storage:Store at -20 degrees Celsius

Sequence:QVPSRPNRAP

Application:

Dynamin Inhibitory Peptide, Myristoylated is a specialized peptide designed to inhibit dynamin's GTPase activity with enhanced cell permeability due to its myristoylation. This modification allows the peptide to effectively penetrate cellular membranes, making it a powerful tool for studying clathrin-mediated endocytosis and vesicle trafficking in live cells. By disrupting dynamin function, this peptide is critical for research on synaptic transmission, receptor internalization, and other membrane-related processes. With its high purity and increased efficacy, Dynamin Inhibitory Peptide, Myristoylated provides reliable and consistent results, making it indispensable in cellular and molecular biology studies.

Current Research:

Dynamin inhibitory peptide, myristoylated (CAS: 251634-22-7), is a cell-permeable decapeptide with the sequence Myr-Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro-NH2. The myristoylation at the N-terminus enhances its ability to traverse cellular membranes, facilitating intracellular access. This peptide functions as a competitive inhibitor of the GTPase dynamin by obstructing its interaction with amphiphysin, thereby impeding clathrin-mediated endocytosis. In neuronal studies, the myristoylated dynamin inhibitory peptide has been instrumental in elucidating receptor internalization mechanisms. For example, it has been shown to reduce NMDA receptor internalization, thereby modulating synaptic transmission and plasticity. Additionally, this peptide has been utilized to investigate the endocytosis of GABA_A receptors, providing insights into inhibitory synaptic regulation. Beyond neuronal applications, this peptide has been employed to study endocytic processes in various cell types, including endothelial cells. By inhibiting dynamin function, researchers can assess the impact on cellular uptake mechanisms, receptor recycling, and signal transduction pathways. This has implications for understanding diseases where dysregulated endocytosis plays a role, such as cancer and neurodegenerative disorders. Despite its research utility, the commercial availability of myristoylated dynamin inhibitory peptide has been limited, with some suppliers discontinuing its sale. Researchers interested in utilizing this compound may need to explore alternative sources or consider custom synthesis to obtain the peptide for their studies. In summary, myristoylated dynamin inhibitory peptide serves as a potent tool for investigating the intricacies of dynamin-mediated endocytosis and its broader implications in cellular physiology and pathology. Its ability to modulate receptor internalization and vesicular trafficking continues to advance our understanding of these fundamental biological processes.

Reference:

Ford, M. G., & Chappie, J. S. (2019). The structural biology of the dynamin-related proteins: New insights into a diverse, multitalented family. Traffic, 20(10), 717-740.