Elcatonin Acetate

Product Name:Elcatonin Acetate

Form:Acetate salt

Purity:95%

Storage:-20^oC

Cas No:60731-46-6

Molar Mass:3363.8

Chemical Formula:C148H244N42O47

IUPAC Name:1,7-Dicarbacalcitonin (salmon), 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine-

SMILES:CC(CC(C(NCC(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(N1CCCC1C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(NCC(NC(C(N2CCCC2C(N)=O)=O)C(O)C)=O)=O)C)=O)=O)C(C)C)=O)CC(O)=O)=O)C(O)C)=O)CCCNC(N)=N)=O)=O)Cc3ccc(O)cc3)=O)C(O)C)=O)CCC(N)=O)=O)CC(C)C)=O)CCCCN)=O)Cc4[nH]cnc4)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CO)=O)CC(C)C)=O)CCCCN)=O)=O)NC(C(C(C)C)NC(C5CCCCCC(OCC(C(NC(C(NC(C(NC(C(NC(C(N5)=O)C(O)C)=O)CO)=O)CC(C)C)=O)CC(N)=O)=O)N)=O)=O)=O)C

InChIKey:JYSJVJJVLNYRKL-UHFFFAOYSA-N

InChI:InChI=1S/C148H244N42O47/c1-69(2)52-92(178-142(231)115(75(13)14)185-128(217)87-30-21-20-22-36-113(208)237-67-84(151)122(211)172-98(59-107(154)200)136(225)176-96(56-73(9)10)134(223)182-102(66-192)139(228)188-116(77(16)193)143(232)171-87)123(212)161-63-109(202)165-85(31-23-25-47-149)124(213)173-95(55-72(7)8)133(222)181-101(65-191)138(227)169-89(41-44-105(152)198)126(215)167-91(43-46-111(204)205)127(216)175-94(54-71(5)6)132(221)177-97(58-82-61-158-68-163-82)135(224)166-86(32-24-26-48-150)125(214)174-93(53-70(3)4)131(220)168-90(42-45-106(153)199)130(219)187-118(79(18)195)145(234)180-100(57-81-37-39-83(197)40-38-81)146(235)190-51-29-35-104(190)140(229)170-88(33-27-49-159-148(156)157)129(218)186-117(78(17)194)144(233)179-99(60-112(206)207)137(226)184-114(74(11)12)141(230)162-62-108(201)164-76(15)121(210)160-64-110(203)183-119(80(19)196)147(236)189-50-28-34-103(189)120(155)209/h37-40,61,68-80,84-104,114-119,191-197H,20-36,41-60,62-67,149-151H2,1-19H3,(H2,152,198)(H2,153,199)(H2,154,200)(H2,155,209)(H,158,163)(H,160,210)(H,161,212)(H,162,230)(H,164,201)(H,165,202)(H,166,224)(H,167,215)(H,168,220)(H,169,227)(H,170,229)(H,171,232)(H,172,211)(H,173,213)(H,174,214)(H,175,216)(H,176,225)(H,177,221)(H,178,231)(H,179,233)(H,180,234)(H,181,222)(H,182,223)(H,183,203)(H,184,226)(H,185,217)(H,186,218)(H,187,219)(H,188,228)(H,204,205)(H,206,207)(H4,156,157,159)

Sequence:SNLST{Asu}VLGKLSQELHKLQTYPRTDVGAGTP-NH2 (Lactam bridge: Ser1-Asu6)

Application:Elcatonin Acetate is a synthetic analog of calcitonin, a peptide hormone that regulates calcium metabolism and bone remodeling. It is primarily used for the treatment of osteoporosis, hypercalcemia, and bone pain associated with fractures or metastatic bone disease. By inhibiting osteoclast activity, Elcatonin reduces bone resorption, preserving bone density. Compared to other calcitonin formulations, it has enhanced stability and longer-lasting effects. Current research explores its neuroprotective potential, pain modulation, and role in metabolic bone disorders, positioning it as a promising candidate for bone health, pain management, and age-related degenerative conditions.

Current Research:Elcatonin Acetate is a synthetic calcitonin analog that plays a crucial role in bone metabolism and calcium homeostasis. As a potent inhibitor of osteoclastic bone resorption, it has been widely used in osteoporosis management, hypercalcemia treatment, and bone pain relief. Recent research is exploring its broader applications in neuroprotection, pain modulation, and metabolic bone diseases. Osteoporosis and Bone Health Elcatonin is a well-established treatment for osteoporosis, particularly in postmenopausal women and elderly patients. Inhibition of bone resorption: By acting on calcitonin receptors in osteoclasts, Elcatonin reduces bone degradation, leading to higher bone mineral density (BMD). Fracture prevention: Studies indicate that long-term use reduces the risk of vertebral fractures in high-risk osteoporosis patients. Comparison with other calcitonins: Research is evaluating the efficacy of Elcatonin against salmon calcitonin and human calcitonin, focusing on potency, bioavailability, and side effects. Hypercalcemia Management Elcatonin is effective in treating hypercalcemia, particularly in patients with parathyroid disorders or malignancy-associated hypercalcemia. Calcium regulation: It enhances calcium excretion via the kidneys, helping control serum calcium levels in hyperparathyroidism and bone metastases. Adjunct therapy in cancer-related hypercalcemia: Studies are assessing its use in combination with bisphosphonates for improved efficacy. Pain Modulation and Analgesic Properties Elcatonin has been studied for its role in reducing bone pain, particularly in patients with osteoporosis-related fractures, Paget??s disease, and metastatic bone disease. Pain relief mechanism: It is believed to act on central pain pathways by modulating neuropeptide signaling, providing analgesic effects independent of bone remodeling. Comparison with opioids and NSAIDs: Research suggests that Elcatonin could serve as a non-opioid alternative for chronic bone pain management. Emerging Research Areas Neuroprotection and neurodegenerative diseases: Studies are exploring Elcatonin??s potential neuroprotective effects, particularly in Alzheimer??s and Parkinson??s disease, due to its influence on calcium signaling in neurons. Cartilage protection and osteoarthritis (OA): Some research indicates it may have chondroprotective properties, helping slow cartilage degradation in osteoarthritis. Chronic inflammatory diseases: Its effects on inflammation and cytokine modulation are being investigated for potential benefits in rheumatoid arthritis and other inflammatory disorders. With expanding research, Elcatonin Acetate is emerging as a promising agent in osteoporosis, pain management, and neurodegenerative disease research, offering potential benefits beyond bone metabolism.

Reference:Aoki, M., Mori, A., Nakahara, T., Sakamoto, K., & Ishii, K. (2012). Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.?European Journal of Pharmacology,?696(1-3), 62-69.