[Lys(Me2)27,Lys(Me1)36]-Histone H3 (21-44)-GK(Biotin)

Product Name: [Lys(Me2)27,Lys(Me1)36]-Histone H3 (21-44)-GK(Biotin)

Sequence One Letter Code: ATKAAR-K(Me2)-SAPATGGV-K(Me1)-KPHRYRPG-GK(Biotin)

Sequence Three Letter Code: H-Ala-Thr-Lys-Ala-Ala-Arg-Lys(Me2)-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys(Me1)-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Lys(Biotin)-OH

Molecular Weight: 2959.7

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Biotins

Code Nacres: NA.26

Application: Histone H3 (21–44), K27me2/K36me1-GK(Biotin) is a synthetic histone H3 peptide containing defined methylation marks: dimethylation at lysine 27 and monomethylation at lysine 36. Both H3K27 and H3K36 methylation play important roles in chromatin structure, transcriptional regulation, and epigenetic signaling. This combinatorially modified peptide enables investigation of histone modification crosstalk, reader protein specificity, and methylation-dependent regulatory mechanisms. The C-terminal glycine linker and biotinylated lysine support affinity capture, pull-down assays, and binding studies. It is valuable for chromatin-associated protein interaction and epigenetic enzyme research.