Neutrophil Elastase Substrate, fluorescent MeOSuc-Ala-Ala-Pro-Val-AFC

Product Name: Neutrophil Elastase Substrate, fluorescent MeOSuc-Ala-Ala-Pro-Val-AFC

Sequence One Letter Code: MeOSuc-AAPV-AFC

Sequence Three Letter Code: MeOSuc-Ala-Ala-Pro-Val-AFC

Chemical Formula:C31H38F3N5O9

Molecular Weight: 681.7

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C Protected from light

Source / Species: Synthetic construct

Conjugation: Conjugated

Conjugation Type: Fluorescent dyes

Code Nacres: NA.26

Application: MeOSuc-Ala-Ala-Pro-Val-AFC is a highly specific fluorogenic substrate for neutrophil elastase, a serine protease involved in innate immune defense, inflammation, and tissue remodeling. Upon enzymatic cleavage, the AFC fluorophore is released, producing a strong fluorescence signal measurable at Abs/Em 380/500 nm. Neutrophil elastase activity is closely associated with chronic inflammatory diseases, lung injury, and neutrophil-driven tissue damage. This peptide substrate is widely used in enzymatic kinetics, elastase activity assays, inhibitor screening, inflammatory disease research, and biochemical studies of neutrophil-mediated proteolytic pathways.