Product Name:Obestatin (human)
CAS No:1081110-72-6
Purity:95%
Molar Mass:2546.86
Chemical Formula:C116H176N32O33
Storage:Store at -20 degrees Celsius
Sequence:FNAPFDVGIKLSGVQYQQHSQAL-NH2
Application:
Obestatin (human) is a peptide hormone derived from the ghrelin gene, though it has opposing effects to ghrelin. While ghrelin is known for stimulating appetite, obestatin is believed to suppress food intake and inhibit gastrointestinal motility. Obestatin binds to GPR39, a G protein-coupled receptor, and has been studied for its potential role in regulating metabolism, body weight, and energy balance. Research into obestatin focuses on its involvement in appetite regulation, obesity, and metabolic disorders, as well as its potential therapeutic applications in weight management and related health conditions.
Current Research:
Obestatin is a 23-amino-acid peptide hormone derived from the ghrelin precursor protein, preproghrelin. It is primarily produced in the specialized epithelial cells of the stomach and small intestine in humans and other animals. Initially identified as an anorexigenic peptide, obestatin was thought to suppress appetite and reduce food intake. However, subsequent studies have yielded inconsistent results regarding its effects on feeding behavior, leading to ongoing debates about its physiological role.
Discovery and Structure
Obestatin was discovered in 2005 through bioinformatics analyses aimed at identifying new peptides encoded by the ghrelin gene. The peptide is amidated at its C-terminus, a modification essential for its biological activity. Nuclear Magnetic Resonance (NMR) studies have revealed that obestatin adopts a structure comprising two alpha-helices, contributing to its stability and interaction with potential receptors.
Receptor Interaction
Initially, GPR39, an orphan G protein-coupled receptor, was proposed as the receptor mediating obestatin's effects. However, subsequent research has challenged this notion, and the exact receptor for obestatin remains unidentified. This uncertainty has complicated efforts to fully understand the peptide's mechanisms of action.
Physiological Functions
Beyond its controversial role in appetite regulation, obestatin has been implicated in various physiological processes:
Gastrointestinal Motility: Some studies suggest that obestatin may inhibit gastric emptying and reduce intestinal motility, potentially counteracting the effects of ghrelin, which promotes gastrointestinal movement.
Cell Proliferation and Apoptosis: Obestatin has been shown to promote cell survival and inhibit apoptosis in pancreatic beta-cells and human islets, indicating a protective role in cellular homeostasis.
Metabolic Regulation: Research indicates that obestatin may influence glucose metabolism and insulin secretion, suggesting potential implications in metabolic disorders.
Clinical Implications
The diverse functions of obestatin have sparked interest in its potential therapeutic applications:
Obesity and Eating Disorders: Given its proposed anorexigenic effects, obestatin or its analogs could be explored as treatments for obesity and related eating disorders.
Diabetes Mellitus: By promoting beta-cell survival and modulating insulin secretion, obestatin-based therapies might offer novel approaches for diabetes management.
Cardiovascular Health: Obestatin's involvement in cardiovascular function suggests it could be a target for treating heart diseases.
Conclusion
Obestatin is a multifaceted peptide hormone with roles extending beyond appetite regulation to include gastrointestinal motility, cell survival, and metabolic processes. Despite initial controversies and ongoing debates regarding its receptor interactions and physiological functions, obestatin remains a significant subject of research, holding promise for therapeutic applications in various health conditions.
Reference:
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