Product Name: Obestatin (rat)
CAS No: 869705-22-6
Purity: 95%
Molar Mass: 2516.8
Chemical Formula: C114H174N34O31
Storage: Store at -20??
Sequence: FNAPFDVGIKLSGAQYQQHGRAL-NH2
Target: GPR39
Application: Obestatin is a peptide hormone derived from the same prohormone as ghrelin, primarily secreted by the stomach. It exerts its effects by binding to GPR39, a G-protein coupled receptor, influencing various physiological processes. Obestatin is known to inhibit food intake, reduce gastric motility, and promote the proliferation of pancreatic ??-cells. It plays a role in energy homeostasis, glucose metabolism, and gastrointestinal function. Due to its involvement in regulating appetite and metabolic processes, Obestatin is a significant focus of research in obesity, diabetes, and gastrointestinal disorders, offering potential therapeutic applications in these areas.
Current Research:
Obestatin, a peptide derived from the ghrelin gene, has gained attention for its unique biological functions distinct from its parent molecule. Originally identified as an anorexigenic hormone, obestatin has since been implicated in a variety of physiological processes, particularly in metabolic regulation and gastrointestinal function.
In rodent models, obestatin has shown the ability to reduce food intake and suppress weight gain by modulating hypothalamic signaling pathways. It acts through the G-protein-coupled receptor GPR39, although its exact receptor interaction and downstream signaling mechanisms remain areas of active investigation. Beyond appetite control, obestatin plays a role in energy homeostasis by influencing lipid and glucose metabolism, suggesting potential therapeutic applications in obesity and diabetes.
Obestatin's effects extend to the gastrointestinal tract, where it contributes to regulating motility and secretion. Studies in rats have demonstrated its capacity to slow gastric emptying and intestinal transit, thereby modulating nutrient absorption and digestion. These properties underscore its potential utility in managing gastrointestinal disorders.
Additionally, obestatin exhibits cardioprotective and cytoprotective properties. Research has highlighted its involvement in reducing oxidative stress and inflammation, particularly in ischemia-reperfusion injury models. This peptide also promotes cell survival and tissue repair, opening avenues for its application in regenerative medicine.
In conclusion, obestatin (rat) represents a versatile molecule with significant implications in metabolic, gastrointestinal, and protective cellular processes. Its multifunctional nature and therapeutic potential make it a promising candidate for further exploration in drug discovery and biomedical research. Ongoing studies aim to unravel its detailed mechanisms and optimize its application in addressing metabolic and gastrointestinal diseases.
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