pep2m

Product Name:pep2m

Synonyms:GluR2m

CAS No:243843-42-7

Purity:95%

Molar Mass:1173.4

Chemical Formula:C49H92N18O13S

Storage:Store at -20 degrees Celsius

Sequence:KRMKVAKNAQ

Application:

pep2m is a specialized peptide with high purity, designed for cutting-edge pharmaceutical and biochemical research. This peptide is crucial for studying receptor-ligand interactions, signal transduction pathways, and cellular communication mechanisms. Its stable structure and consistent activity make it an ideal candidate for detailed analysis and experimental applications. pep2m is synthesized using advanced techniques to ensure minimal batch-to-batch variability, providing reliable results across different research setups. Whether used in drug development, molecular biology, or therapeutic research, pep2m offers a robust and cost-effective solution for precise and reproducible scientific investigations.

Current Research:

pep2m (CAS: 243843-42-7) is a synthetic decapeptide with the sequence KRMKVAKNAQ. It functions as an inhibitor of the interaction between the C-terminus of the GluA2 subunit of AMPA receptors and the N-ethylmaleimide-sensitive fusion protein (NSF), a key regulator of AMPA receptor function. By disrupting the GluA2-NSF interaction, pep2m reduces AMPA receptor-mediated postsynaptic currents and decreases the surface expression of these receptors in neurons. This modulation of synaptic transmission has made pep2m a valuable tool in neuroscience research, particularly in studies investigating synaptic plasticity and the molecular mechanisms underlying learning and memory. In experimental settings, pep2m has been shown to reduce postsynaptic currents in CA1 neurons and diminish AMPA-mediated currents in cultured hippocampal neurons. These effects are attributed to its ability to interfere with the GluA2-NSF interaction, leading to altered AMPA receptor trafficking and function. For laboratory use, pep2m is typically stored desiccated at -20 degrees Celsius to maintain its stability. It is soluble up to 2 mg/mL in 20% acetonitrile, facilitating its application in various experimental protocols. In summary, pep2m serves as a potent inhibitor of the GluA2-NSF interaction, offering researchers a means to modulate AMPA receptor function and investigate the complex processes of synaptic transmission and plasticity.

Reference:

Yao, Y., Kelly, M. T., Sajikumar, S., Serrano, P., Tian, D., Bergold, P. J., ... & Sacktor, T. C. (2008). PKM maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Journal of Neuroscience, 28(31), 7820-7827.