[Pyr1]-Apelin-13

Product Name:[Pyr1]-Apelin-13

CAS No:217082-60-5

Purity:95%

Molar Mass:1533.81

Chemical Formula:C69H108N22O16S

Storage:Store at -20 degrees Celsius

Sequence:XRPRLSHKGPMPF

Application:

[Pyr1]-Apelin-13 is a synthetic peptide analog of the naturally occurring apelin-13, which plays a key role in cardiovascular regulation, energy metabolism, and fluid homeostasis. The modification with a pyroglutamic acid residue at the N-terminal ([Pyr1]) enhances its stability and biological activity. This peptide is widely used in research focusing on apelin receptor signaling pathways, especially in studies related to hypertension, heart failure, and metabolic disorders. Its high affinity for the APJ receptor makes it a valuable tool for investigating therapeutic strategies aimed at cardiovascular diseases and metabolic regulation.

Current Research:

[Pyr1]-Apelin-13, a biologically active peptide derived from the apelin signaling pathway, has garnered significant attention in current biomedical research due to its diverse physiological roles and therapeutic potential. As an endogenous ligand for the G protein-coupled apelin receptor (APJ), [Pyr1]-Apelin-13 is involved in critical processes such as cardiovascular regulation, fluid homeostasis, and metabolic modulation. One of the primary research focuses lies in its cardioprotective properties. Studies have demonstrated that [Pyr1]-Apelin-13 exerts potent vasodilatory effects, enhances cardiac contractility, and attenuates myocardial ischemia-reperfusion injury. These findings have positioned it as a promising therapeutic candidate for heart failure and hypertension. Recent investigations are exploring its interaction with angiotensin II and its potential to mitigate pathological cardiac remodeling, providing insights into novel combination therapies for cardiovascular diseases. Beyond cardiology, [Pyr1]-Apelin-13 is being studied in the context of metabolic disorders, including type 2 diabetes and obesity. Research highlights its ability to regulate glucose uptake, lipid metabolism, and insulin sensitivity, presenting opportunities for its development as a metabolic regulator. Furthermore, its role in energy homeostasis has implications for obesity-related complications, a burgeoning area of interest in translational medicine. Emerging studies also indicate the peptide's involvement in neuroprotection. By modulating neuroinflammatory pathways and blood-brain barrier integrity, [Pyr1]-Apelin-13 shows potential in addressing neurodegenerative conditions such as Alzheimer's disease and stroke. Researchers are investigating its pharmacokinetics and receptor-specific mechanisms to optimize its therapeutic application. As a multifunctional peptide, [Pyr1]-Apelin-13 continues to drive research at the intersection of physiology, pharmacology, and molecular biology. Ongoing preclinical and clinical studies aim to unravel its full therapeutic potential, solidifying its role in addressing complex diseases through targeted modulation of the apelin signaling pathway.

Reference:

Maguire, J. J., Kleinz, M. J., Pitkin, S. L., & Davenport, A. P. (2009). [Pyr1] apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension, 54(3), 598-604.