Renin FRET substrate, Dabcyl/EDANS

Product Name: Renin FRET substrate, Dabcyl/EDANS

Sequence One Letter Code: DABCYL-g-Abu-IHPFHLVIHT-EDANS

Sequence Three Letter Code: DABCYL - g - Abu - Ile - His - Pro - Phe - His - Leu - Val - Ile - His - Thr - EDANS

Cas No: 142988-22-5

Chemical Formula:C96H126N22O16S

Molecular Weight: 1798.2

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C Protected from light

Source / Species: human

Conjugation: Conjugated

Conjugation Type: Double dyes

Code Nacres: NA.26

Application: Renin Substrate I FRET Peptide is a fluorogenic substrate designed for continuous measurement of human renin activity. It contains the natural angiotensinogen renin cleavage site, with specific hydrolysis occurring at the Leu–Val bond. The intact peptide uses intramolecular FRET quenching between DABCYL and EDANS, while renin-mediated cleavage restores fluorescence detectable at Abs/Em 355/500 nm. This substrate enables highly sensitive renin assays, kinetic analysis, and inhibitor screening. Renin Substrate I FRET Peptide is widely used in cardiovascular research, hypertension studies, renin–angiotensin system biology, and drug discovery targeting renin activity.