S3 Fragment, ADF/cofilin, LIMK1 substrate

Product Name: S3 Fragment, ADF/cofilin, LIMK1 substrate

Sequence One Letter Code: MASGVMVSDDVVKVFN

Sequence Three Letter Code: H-Met-Ala-Ser-Gly-Val-Met-Val-Ser-Asp-Asp-Val-Val-Lys-Val-Phe-Asn-OH

Chemical Formula:C73H120N18O24S2

Molecular Weight: 1698.1

Purity: ≥ 95%

Form: Lyophilized

Storage Conditions: - 20 °C

Source / Species: Xenopus

Conjugation: Unconjugated

Code Nacres: NA.26

Application: ADF/Cofilin S3 Fragment Peptide corresponds to the amino-terminal phosphorylation site of ADF/cofilin containing serine 3, the target residue of LIM kinase 1. Phosphorylation of cofilin at serine 3 by LIMK1 promotes actin filament stabilization and cytoskeletal remodeling. This peptide has been widely used as a competitive substrate and inhibitor of LIMK1 activity. ADF/Cofilin S3 Fragment Peptide is valuable for studying actin dynamics, cytoskeletal regulation, kinase signaling, cell motility, cell morphology, neuronal development, and molecular pathways controlling actin-dependent structural changes in cellular systems.